[ CAS No. 163439-82-5 ] {[proInfo.proName]}

Name: 163439-82-5|(3R,4R)-1-Benzylpyrrolidine-3,4-diol|98%
Brand: Ambeed
SKU: A352692
Price: 19.0 USD
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Quality Control of [ 163439-82-5 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 163439-82-5 ]

SDS Specification

Alternatived Products of [ 163439-82-5 ]

Product Details of [ 163439-82-5 ]

CAS No. :	163439-82-5	MDL No. :	MFCD01073894
Formula :	C₁₁H₁₅NO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QJRIUWQPJVPYSO-GHMZBOCLSA-N
M.W :	193.24	Pubchem ID :	7021491
Synonyms :

Calculated chemistry of [ 163439-82-5 ]

Physicochemical Properties

Num. heavy atoms :	14
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.45
Num. rotatable bonds :	2
Num. H-bond acceptors :	3.0
Num. H-bond donors :	2.0
Molar Refractivity :	57.66
TPSA :	43.7 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.27 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.75
Log Po/w (XLOGP3) :	0.3
Log Po/w (WLOGP) :	-0.31
Log Po/w (MLOGP) :	0.58
Log Po/w (SILICOS-IT) :	0.83
Consensus Log Po/w :	0.63

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.41
Solubility :	7.48 mg/ml ; 0.0387 mol/l
Class :	Very soluble
Log S (Ali) :	-0.78
Solubility :	32.1 mg/ml ; 0.166 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.64
Solubility :	4.43 mg/ml ; 0.0229 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.97

Safety of [ 163439-82-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 163439-82-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 163439-82-5 ]
Downstream synthetic route of [ 163439-82-5 ]

[ 163439-82-5 ] Synthesis Path-Upstream 1~6

1
[ 75172-31-5 ]
[ 163439-82-5 ]

Yield	Reaction Conditions	Operation in experiment
88.5%	With borane-THF In tetrahydrofuran at 70℃; for 3 h;	Borane in THF (1.0 M) (17.19 mL, 180.99 mmol) was added drop-wise to a solution of 2a (10.0 g, 45.24 mmol) in THF (200 mL) at RT, after completion of addition, reaction mixture was slowly heated to 70 °C for 3 h. The reaction mixture was cooled to 0 °C, quenched with methanol (50 mL) by the drop-wise addition, slowly warmed to RT, stirred for 1 h. (Note: intensive gas evolution is occurred). The reaction mixture was concentrated in vacuo, crude was purified on a silica gel column using a linear gradient of ethyl acetate in Pet-ether yielding 7.73 g (88.5percent) of yellowish crystals of compound 3a. SOR (MeOH, 0.5percent): +22.800°; ¹H NMR (400 MHz, DMSO-d₆) δ 7.51-7.49 (2H, m), 7.39-7.37 (3H, m), 5.45 (1H, d, J = 4.4 Hz, OH), 5.20 (1H, d, J = 5.2 Hz, OH), 4.15-4.11 (1H, m), 4.04-3.94 (2H, m), 3.90-3.85 (1H, m), 3.48-3.43 (1H, m), 3.10-3.06 (1H, m), 2.97-2.93 (1H, m), 2.89-2.86 (1H, m); ¹³C NMR (100 MHz, DMSO-d₆) δ 132.86, 128.97, 128.51, 127.73, 76.27, 65.47, 63.24; LC-MS (ESI) m/z Calcd. for C₁₁H₁₅NO₂ [M+H]⁺: 193.11, Found 194.20

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 12, p. 2818 - 2823
[2] Synlett, 2009, # 12, p. 1945 - 1948

2
[ 187032-53-7 ]
[ 163439-82-5 ]

Yield	Reaction Conditions	Operation in experiment
86%	With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran; toluene at 0 - 20℃; for 2 h;	Step 2: (3R,4R)-1-Benzylpyrrolidine-3,4-diol To a mechanically stirred and cooled solution (0° C.) of the product from Step 1 (50 g, 0.23 mol) in dry THF (1.24 L) was added sodium aluminum hydride bis-(methoxyethoxide) (289 mL of a 65percent Red-A;.(R)./Toluene solution, 0.95 mol) under a nitrogen atmosphere at such a rate that the internal temperature did not exceed 20° C. The reaction mixture was allowed stir at room temperature for 2 h after the addition was complete. The reaction mixture was slowly poured into ice water (1.0 L) with stirring to quench the reaction. After warming to room temperature, 30percent ammonium hydroxide (100 mL) was added followed by EtOAc (1.5 L) and this mixture was stirred for 16 h. The suspension was filtered through diatomaceous earth and the solids were washed with EtOAc. The filtrate layers were separated and the organic phase was dried over sodium sulfate and concentrated to afford a syrup. Dissolution in dichloromethane and concentration affords a white solid that is collected and dried (43.7 g, 86percent). ¹H NMR (400 MHz, CDCl₃) δ 7.36-7.23 (5H, m), 6.23 (2H, m), 4.65 (1H, m), 4.15-4.00 (3H, m), 3.62-3.49 (1H, dd), 3.33 (1H, dd), 3.14 (1H, dd), 2.94 (1H dd). MS m/z 194 (MH⁺). Step 2: (3R,4R)-1-Benzylpyrrolidine-3,4-diolTo a mechanically stirred and cooled solution (0° C.) of the product from Step 1 (50 g, 0.23 mol) in dry THF (1.24 L) was added sodium aluminum hydride bis-(methoxyethoxide) (289 mL of a 65percent Red-Al.(R)./Toluene solution, 0.95 mol) under a nitrogen atmosphere at such a rate that the internal temperature did not exceed 20° C. The reaction mixture was allowed stir at room temperature for 2 h after the addition was complete. The reaction mixture was slowly poured into ice water (1.0 L) with stirring to quench the reaction. After warming to room temperature, 30percent ammonium hydroxide (100 mL) was added followed by EtOAc (1.5 L) and this mixture was stirred for 16 h. The suspension was filtered through diatomaceous earth and the solids were washed with EtOAc. The filtrate layers were separated and the organic phase was dried over sodium sulfate and concentrated to afford a syrup. Dissolution in methylene chloride and concentration affords a white solid that is collected and dried (43.7 g, 86percent). ¹H NMR (300 MHz, CDCl₃) δ 7.36-7.23 (5H, m), 6.23 (2H, m), 4.65 (1H, m), 4.15-4.00 (3H, m), 3.62-3.49 (1H, dd), 3.33 (1H, dd), 3.14 (1H, dd), 2.94 (1H dd). MS m/z 194 (MH⁺).

Reference： [1] Tetrahedron Letters, 2005, vol. 46, # 49, p. 8521 - 8524
[2] Tetrahedron, 2007, vol. 63, # 5, p. 1243 - 1253
[3] Patent: US2007/299076, 2007, A1, . Location in patent: Page/Page column 11; 14
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 7, p. 2078 - 2087
[5] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 15, p. 4130 - 4133
[6] Tetrahedron Asymmetry, 1997, vol. 8, # 11, p. 1861 - 1867
[7] Journal of Organic Chemistry, 2000, vol. 65, # 6, p. 1750 - 1757
[8] Chemical Research in Toxicology, 2010, vol. 23, # 1, p. 118 - 133
[9] Journal of Labelled Compounds and Radiopharmaceuticals, 1999, vol. 42, # 12, p. 1145 - 1159
[10] Chemische Berichte, 1986, vol. 119, # 11, p. 3326 - 3343
[11] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 16, p. 2385 - 2390
[12] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 5, p. 1265 - 1268
[13] Patent: WO2015/124941, 2015, A1, . Location in patent: Page/Page column 87; 88

3
[ 50623-73-9 ]
[ 100-46-9 ]
[ 163439-82-5 ]

Yield	Reaction Conditions	Operation in experiment
46%	Stage #1: for 96 h; Heating / reflux Stage #2: With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃;	To a 1,4-dioxane (20 mL) solution of 1,4-di-O-tosyl-D-threitol (9.15 g, 21.25 mmol), benzylamine (9.29 mL, 85.0 mmol) was added, and the mixture was heated to reflux under a nitrogen stream for 4 days while stirring. The reaction liquor was returned to room temperature, and then a saturated aqueous solution of sodium hydrogen carbonate (50 mL) was added. The mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was purified by column chromatography using silica gel [NH(basic)-silica gel 100 g, ethyl acetate to chloroform/methanol (10/1)], to obtain the title compound (1.88 g, 46percent) as an oily matter. NMR(CDCl₃)δ:2.49(2H,dd,J=10.4,3.3Hz),3.01(2H,dd,J=10.0,5.4Hz),3.68(2H,s),4.08-4.13(2H,m),7.35-7.27(5H,m).

Reference： [1] Patent: EP1961750, 2008, A1, . Location in patent: Page/Page column 122

4
[ 109-63-7 ]
[ 187032-53-7 ]
[ 163439-82-5 ]

Reference： [1] Patent: US5952363, 1999, A,

5
[ 100-46-9 ]
[ 163439-82-5 ]

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 12, p. 2818 - 2823

6
[ 147-71-7 ]
[ 100-46-9 ]
[ 163439-82-5 ]

Reference： [1] Collection of Czechoslovak Chemical Communications, 2012, vol. 77, # 3, p. 224 - 233

[ 163439-82-5 ] Synthesis Path-Downstream 1~49

1
[ 124-63-0 ]
[ 163439-82-5 ]
[ 380357-38-0 ]

Yield	Reaction Conditions	Operation in experiment
67.6%	With triethylamine; In dichloromethane; at 0 - 20℃;Product distribution / selectivity;	Step 3: (3R,4R)-1-Benzyl-3,4-bis(methylsulfonyloxy)pyrrolidine To an ice-cold (0-5 C.) solution of the product from Step 2 (5.27 g, 27.3 mmol) and TEA (8.27 g, 81.9 mmol) in dichloromethane (50 mL), was added methanesulfonyl chloride (6.87 g, 60.0 mmol) over a period of 30 minutes. After stirring at RT overnight, the reaction mixture was washed with water. The organic layer was dried (sodium sulfate), filtered, and concentrated to give the crude product which was purified over a silica column (5:95 EtOAc/hexane) to obtain pure product (6.44 g, 67.6%). 1H NMR (400 MHz, CDCl3) delta 7.32-7.26 (5H, m), 5.14 (2H, m), 3.65 (2H, s), 3.15-3.08 (2H, m), 3.08 (6H, s), 2.76 (2H, dd). MS m/z 350 (MH+). Step 3: (3R,4R)-1-Benzyl-3,4-bis(methylsulfonyloxy)pyrrolidineTo an ice-cold (0-5 C.) solution of the product from Step 2 (5.27 g, 27.3 mmol) and TEA (8.27 g, 81.9 mmol) in dichloromethane (50 mL), was added methanesulfonyl chloride (6.87 g, 60.0 mmol) over a period of 30 minutes. After stirring at RT overnight, the reaction mixture was washed with water. The organic layer was dried (sodium sulfate), filtered, and concentrated to give the crude product which was purified over a silica column (5:95 EtOAc/hexane) to obtain pure product (6.44 g, 67.6%). 1H NMR (300 MHz, CDCl3) delta 7.32-7.26 (5H, m), 5.14 (2H, m), 3.65 (2H, s), 3.15-3.08 (2H, m), 3.08 (6H, s), 2.76 (2H, dd). MS m/z 350 (MH+).

Reference： [1]Soft Matter,2015,vol. 11,p. 8333 - 8341
[2]Patent: US2007/299076,2007,A1 .Location in patent: Page/Page column 11; 14
[3]Chemische Berichte,1986,vol. 119,p. 3326 - 3343
[4]Synlett,2009,p. 1945 - 1948

2
[ 187032-53-7 ]
[ 163439-82-5 ]

Yield	Reaction Conditions	Operation in experiment
86%	With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 0 - 20℃; for 2h;Product distribution / selectivity;	Step 2: (3R,4R)-1-Benzylpyrrolidine-3,4-diol To a mechanically stirred and cooled solution (0 C.) of the product from Step 1 (50 g, 0.23 mol) in dry THF (1.24 L) was added sodium aluminum hydride bis-(methoxyethoxide) (289 mL of a 65% Red-A;/Toluene solution, 0.95 mol) under a nitrogen atmosphere at such a rate that the internal temperature did not exceed 20 C. The reaction mixture was allowed stir at room temperature for 2 h after the addition was complete. The reaction mixture was slowly poured into ice water (1.0 L) with stirring to quench the reaction. After warming to room temperature, 30% ammonium hydroxide (100 mL) was added followed by EtOAc (1.5 L) and this mixture was stirred for 16 h. The suspension was filtered through diatomaceous earth and the solids were washed with EtOAc. The filtrate layers were separated and the organic phase was dried over sodium sulfate and concentrated to afford a syrup. Dissolution in dichloromethane and concentration affords a white solid that is collected and dried (43.7 g, 86%). 1H NMR (400 MHz, CDCl3) delta 7.36-7.23 (5H, m), 6.23 (2H, m), 4.65 (1H, m), 4.15-4.00 (3H, m), 3.62-3.49 (1H, dd), 3.33 (1H, dd), 3.14 (1H, dd), 2.94 (1H dd). MS m/z 194 (MH+). Step 2: (3R,4R)-1-Benzylpyrrolidine-3,4-diolTo a mechanically stirred and cooled solution (0 C.) of the product from Step 1 (50 g, 0.23 mol) in dry THF (1.24 L) was added sodium aluminum hydride bis-(methoxyethoxide) (289 mL of a 65% Red-Al/Toluene solution, 0.95 mol) under a nitrogen atmosphere at such a rate that the internal temperature did not exceed 20 C. The reaction mixture was allowed stir at room temperature for 2 h after the addition was complete. The reaction mixture was slowly poured into ice water (1.0 L) with stirring to quench the reaction. After warming to room temperature, 30% ammonium hydroxide (100 mL) was added followed by EtOAc (1.5 L) and this mixture was stirred for 16 h. The suspension was filtered through diatomaceous earth and the solids were washed with EtOAc. The filtrate layers were separated and the organic phase was dried over sodium sulfate and concentrated to afford a syrup. Dissolution in methylene chloride and concentration affords a white solid that is collected and dried (43.7 g, 86%). 1H NMR (300 MHz, CDCl3) delta 7.36-7.23 (5H, m), 6.23 (2H, m), 4.65 (1H, m), 4.15-4.00 (3H, m), 3.62-3.49 (1H, dd), 3.33 (1H, dd), 3.14 (1H, dd), 2.94 (1H dd). MS m/z 194 (MH+).
	With lithium aluminium tetrahydride; In tetrahydrofuran; at 0℃; for 16h;Reflux;	LiAIH4 (2M in THF, 18.5 ml,37 mmol) was slowly added with stirringto a solution of 1820 (3 g, 13.6 mmol) in THF (90 ml)at 0 C. The reaction mixturewas heated at reflux for 16 h, cooled to 0oc and slowlyquenched with H20 (1.48 ml), aqueous NaOH (15% wt. inH20, 1.48 ml)and H20 (4.5 ml). The reactionmixture was filteredthrough Celite, washed with hot THF (50 ml)and the filtratewas concentrated in vacuo to give crude (3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine as a pale yellow solid,which was used for the25 next step without further purification. The crude benzylpyrrolidine inMeOH (35 ml) was allowedto react with Boc20 (3.26g, 15 mmol) and Pd/C (10% wt., 300 mg) and stirredunder an atmosphere of hydrogen for 16h. The mixture was filtered throughCelite, concentrated under reduced pressureand the30 residue was recrystallized from hot EtOAc (25 ml)yielding19 (2.0 g, 72%) as pale yellow crystals.

Reference： [1]Tetrahedron Letters,2005,vol. 46,p. 8521 - 8524
[2]Tetrahedron,2007,vol. 63,p. 1243 - 1253
[3]Patent: US2007/299076,2007,A1 .Location in patent: Page/Page column 11; 14
[4]Journal of Medicinal Chemistry,2008,vol. 51,p. 2078 - 2087
[5]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 4130 - 4133
[6]Tetrahedron Asymmetry,1997,vol. 8,p. 1861 - 1867
[7]Journal of Organic Chemistry,2000,vol. 65,p. 1750 - 1757
[8]Chemical Research in Toxicology,2010,vol. 23,p. 118 - 133
[9]Journal of labelled compounds and radiopharmaceuticals,1999,vol. 42,p. 1145 - 1159
[10]Chemische Berichte,1986,vol. 119,p. 3326 - 3343
[11]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 2385 - 2390
[12]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 1265 - 1268
[13]Patent: WO2015/124941,2015,A1 .Location in patent: Page/Page column 87; 88

3
[ 163439-82-5 ]
[ 186393-31-7 ]

Yield	Reaction Conditions	Operation in experiment
100%	With hydrogen; at 50℃; for 26h;	A dry 5 mL round-bottomed flask containing a magnetic stirring bar was charged with <strong>[163439-82-5](3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine</strong> diol 5 (0.45 g, 2.3 mmol), EtOH (15 mL) and Pd(0)En cat 3NP (1 g, 0.4 mmol Pd/g). A balloon filled with hydrogen was attached to the flask, the mixture was warmed to 50 C and stirred for 26 h. It was then allowed to cool to room temperature, filtered and washed with CH2Cl2 (3 mL), and the solvent was removed in vacuo giving 7 (0.24 g, 100%) as a white solid. 1H NMR (400 MHz, D2O): delta 3.36 ppm (d, J 12 Hz, CHH, 2H), 3.6 (d, J 12 Hz, CHH, 2H), 4.41 (s, 2H, CHO, 2H). 13C NMR (D2O, 100 MHz): delta 49.2 ppm, 72.7.
82%	With palladium 10% on activated carbon; hydrogen; In ethanol; at 20℃; under 5171.62 Torr; for 24h;	10 % Pd/C (1.50 g) was added to solution of 3a (7.50 g, 38.86 mmol) in ethanol (40 mL) under argon atmosphere, hydrogenated under 100 psi at room temperature for 24 h. The reaction mixture was filtered through celite pad, filtrate was evaporated in vacuo to get crude. The crude product was washed with n-pentane-diethyl ether mixture (1:1) (20 mL), decanted the organic layer and dried in vacuo yielding 3.28 g (82.0 %) of light brown solid of compound 4a. SOR (MeOH, 0.5%): +2.000; 1H NMR (300 MHz, DMSO-d6) delta 4.60 (2H, s, br, OH), 3.77 (2H, dd, J = 3.6, 1.5 Hz), 2.90 (2H, dd, J = 11.4, 4.4 Hz), 2.50-2.48 (2H, m), 2.46 (1H, s); 13C NMR (75 MHz, DMSO-d6) delta 74.10, 50.19; MS (ESI) m/z Calcd. for C4H9NO2 [M+H]+: 103.06, Found 103.95
	With hydrogen;palladium on carbon; In methanol; at 20℃; under 2327.23 Torr;	a) A mixture of (3R, 4R)-benzyl-3, 4-pyrrolidindiol (compound 30.1, 1 mmol) and 20% Pd (OH) 2/C (0.1 mmol) in methanol (10 mL) is shaken at room temperature for several hours under 45 psi of H2. (g). The reaction mixture is filtered, the filtrate is concentrated, and the residue is dried in vacuo to give compound 30.2.

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 4130 - 4133
[2]Bioorganic Chemistry,2014,vol. 54,p. 81 - 88
[3]Chemical Research in Toxicology,2010,vol. 23,p. 118 - 133
[4]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 2385 - 2390
[5]Tetrahedron,2007,vol. 63,p. 1243 - 1253
[6]Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,p. 2818 - 2823
[7]Journal of Organic Chemistry,1995,vol. 60,p. 3100 - 3106
[8]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 1265 - 1268
[9]Patent: WO2005/44817,2005,A1 .Location in patent: Page/Page column 125

4
[ 58479-61-1 ]
[ 163439-82-5 ]
(3R,4R)-3,4-Bis<(tert-butyldiphenylsilyl)oxy>-N-benzylpyrrolidine [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1995,vol. 60,p. 6806 - 6812

5
[ 163439-82-5 ]
[ 288313-99-5 ]

Reference： [1]Journal of Organic Chemistry,2000,vol. 65,p. 1750 - 1757
[2]Tetrahedron Asymmetry,1997,vol. 8,p. 1861 - 1867
[3]Soft Matter,2015,vol. 11,p. 8333 - 8341

6
[ 98-88-4 ]
[ 163439-82-5 ]
[ 259191-44-1 ]

Reference： [1]Journal of labelled compounds and radiopharmaceuticals,1999,vol. 42,p. 1145 - 1159

7
[ 882-33-7 ]
[ 163439-82-5 ]
(3S,4S)-1-Benzyl-3,4-bis-phenylsulfanyl-pyrrolidine [ No CAS ]

Reference： [1]Synlett,2003,p. 1615 - 1618

8
[ 109-65-9 ]
[ 163439-82-5 ]
(3R,4R)-1-Benzyl-1-butyl-3,4-dihydroxy-pyrrolidinium; bromide [ No CAS ]

Reference： [1]Helvetica Chimica Acta,2004,vol. 87,p. 3167 - 3181

9
[ 74-96-4 ]
[ 163439-82-5 ]
(3R,4R)-1-Benzyl-1-ethyl-3,4-dihydroxy-pyrrolidinium; bromide [ No CAS ]

Reference： [1]Helvetica Chimica Acta,2004,vol. 87,p. 3167 - 3181

10
[ 106-94-5 ]
[ 163439-82-5 ]
(3R,4R)-1-Benzyl-3,4-dihydroxy-1-propyl-pyrrolidinium; bromide [ No CAS ]

Reference： [1]Helvetica Chimica Acta,2004,vol. 87,p. 3167 - 3181

11
[ 358-23-6 ]
[ 163439-82-5 ]
Trifluoro-methanesulfonic acid (3R,4R)-1-benzyl-4-trifluoromethanesulfonyloxy-pyrrolidin-3-yl ester [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 4770 - 4773

12
[ 40615-36-9 ]
[ 163439-82-5 ]
[ 926912-77-8 ]