[ CAS No. 51307-43-8 ] {[proInfo.proName]}

Name: 51307-43-8|(2-Aminothiazol-4-yl)methanol|95%
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Quality Control of [ 51307-43-8 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 51307-43-8 ]

CAS No. :	51307-43-8	MDL No. :	MFCD08275702
Formula :	C₄H₆N₂OS	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	FNXARVNPSVMCEY-UHFFFAOYSA-N
M.W :	130.17	Pubchem ID :	16766621
Synonyms :

Calculated chemistry of [ 51307-43-8 ]

Physicochemical Properties

Num. heavy atoms :	8
Num. arom. heavy atoms :	5
Fraction Csp3 :	0.25
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	2.0
Molar Refractivity :	32.65
TPSA :	87.38 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.26 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.9
Log Po/w (XLOGP3) :	-0.24
Log Po/w (WLOGP) :	0.07
Log Po/w (MLOGP) :	-1.08
Log Po/w (SILICOS-IT) :	1.29
Consensus Log Po/w :	0.19

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-0.89
Solubility :	16.7 mg/ml ; 0.128 mol/l
Class :	Very soluble
Log S (Ali) :	-1.14
Solubility :	9.49 mg/ml ; 0.0729 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-0.73
Solubility :	24.4 mg/ml ; 0.187 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.35

Safety of [ 51307-43-8 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 51307-43-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 51307-43-8 ]
Downstream synthetic route of [ 51307-43-8 ]

[ 51307-43-8 ] Synthesis Path-Upstream 1~5

1
[ 5398-36-7 ]
[ 51307-43-8 ]

Reference： [1] Journal of the American Chemical Society, 1950, vol. 72, p. 5221,5224
[2] Patent: WO2011/14795, 2011, A2, . Location in patent: Page/Page column 92

2
[ 59608-97-8 ]
[ 51307-43-8 ]

Reference： [1] Journal of the American Chemical Society, 1946, vol. 68, p. 2155,2158
[2] Chemical and Pharmaceutical Bulletin, 1993, vol. 41, # 9, p. 1589 - 1595
[3] Patent: EP224919, 1991, B1,

3
[ 38987-72-3 ]
[ 17356-08-0 ]
[ 51307-43-8 ]

Yield	Reaction Conditions	Operation in experiment
80%	for 1.5 h; Heating / reflux	1-Bromo-3-hydroxypropan-2-one (60 g, 392 mmol) and thiourea (34 g, 451 mmol) were charged into a 1 L round bottom flask containing 400 mL of EtOH. The resulting mixture was heated to reflux for 90 minutes. The reaction mixture was then cooled and concentrated under reduced pressure, and a precipitate formed. The product was obtained as a solid (40 g, yield=80percent) after filtration and washing three times with hexane. The product was used directly in the next step without further purification. LCMS (API-ES) m/z (percent) 131.2 (100percent, M⁺+H).

Reference： [1] Patent: US2007/173506, 2007, A1, . Location in patent: Page/Page column 34

4
[ 1192-50-3 ]
[ 17356-08-0 ]
[ 51307-43-8 ]

Reference： [1] Journal of the American Chemical Society, 1946, vol. 68, p. 2155,2158

5
[ 89713-01-9 ]
[ 51307-43-8 ]

Reference： [1] Chemische Berichte, 1963, vol. 96, p. 357 - 362

[ 51307-43-8 ] Synthesis Path-Downstream 1~14

1
[ 1192-50-3 ]
[ 17356-08-0 ]
[ 51307-43-8 ]

Reference： [1]Sprague et al. [Journal of the American Chemical Society, 1946, vol. 68, p. 2155,2158]

2
[ 5398-36-7 ]
[ 51307-43-8 ]

Yield	Reaction Conditions	Operation in experiment
	With lithium aluminium tetrahydride
	Stage #1: 2-aminothiazole-4-carboxylate With lithium borohydride In tetrahydrofuran at 0 - 20℃; Stage #2: With water In tetrahydrofuran at 0℃;	6.A Ethyl 2-aminothiazole-4-carboxylate (0.86 g, 5.0 mmol) was slowly added to 2.0 M LiBH4 inTHF solution (3.0 mL, 6.0 mmol) at 0 0C. The reaction mixture was allowed to warm up to room temperature and then stirred overnight. The mixture was then quenched with H2O (30 mL) at 0 0C and extracted with ethyl acetate (3 x 15 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered, concentrated, and purified by silica gel chromatography (10% methanol/dichloromethane) to give (2- aminothiazol-4-yl)methanol as a white solid product.

Reference： [1]Conover; Tarbell [Journal of the American Chemical Society, 1950, vol. 72, p. 5221,5224]
[2]Current Patent Assignee: IRM LLC - WO2011/14795, 2011, A2 Location in patent: Page/Page column 92

3
[ 59608-97-8 ]
[ 51307-43-8 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydroxide; In methanol; water;	(1) A mixture of 2-amino-4-chloromethylthiazol hydrochloride (69 g) and water (500 ml) was refluxed for 1 hour and the reaction mixture was concentrated. The residue was adjusted to pH 7.5 with a solution of potassium hydroxide (37 g) in methanol (300 ml) under ice-cooling with stirring. The insoluble material was filtered off and the filtrate was concentrated to give a residue including 2-amino-4-hydroxymethylthiazole.

Reference： [1]Journal of the American Chemical Society,1946,vol. 68,p. 2155,2158
[2]Chemical and Pharmaceutical Bulletin,1993,vol. 41,p. 1589 - 1595
[3]Patent: EP224919,1991,B1

4
[ 89713-01-9 ]
[ 51307-43-8 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol Heating;

Reference： [1]Albers,H.; Mohler,W. [Chemische Berichte, 1963, vol. 96, p. 357 - 362]

5
[ 51307-43-8 ]
[ 108-24-7 ]
[ 111608-67-4 ]

Yield	Reaction Conditions	Operation in experiment
30%	Stage #1: 2-amino-4-hydroxymethylthiazole; acetic anhydride In 1,4-dioxane for 1h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In 1,4-dioxane; water	10; 11; 12 2-Aminothiazol-4-yl-methanol (17 g, 131 mmol) and acetic anhydride (927 g, 261 mmol) were mixed in 100 mL dioxane in a 500 mL round bottom flask. The mixture was heated at reflux for 1 hour. After the solvent was evaporated, 300 mL saturated sodium bicarbonate was added to the flask. The mixture was extracted twice with 200 mL EtOAc. The combined organic layers were washed with brine and dried over sodium sulfate. After evaporating the solvent, the remaining residue was washed with hexane and ether three times each. This procedure provided 10 g of (2-acetamidothiazol-4-yl)methyl acetate (yield=30%). LCMS (API-ES) m/z (%) 215.2 (100%, M++H).
	With pyridine Ambient temperature; Yield given;

Reference： [1]Current Patent Assignee: AMGEN INC - US2007/173506, 2007, A1 Location in patent: Page/Page column 34
[2]Shigenaga; Manabe; Matsuda; Fujii; Hiroi; Matsuo [Chemical and Pharmaceutical Bulletin, 1993, vol. 41, # 9, p. 1589 - 1595]

6
[ 51307-43-8 ]
[ 1795-48-8 ]
[ 239097-69-9 ]

Yield	Reaction Conditions	Operation in experiment
44%	In acetonitrile at 20 - 50℃; for 3h;

Reference： [1]Murakami, Yasushi; Hara, Hirokazu; Okada, Tetsuo; Hashizume, Hiroshi; Kii, Makoto; Ishihara, Yasunobu; Ishikawa, Michio; Shimamura, Mayumi; Mihara, Shin-Inchi; Kato, Goro; Hanasaki, Kohji; Hagishita, Sanji; Fujimoto, Masafumi [Journal of Medicinal Chemistry, 1999, vol. 42, # 14, p. 2621 - 2632]

7
[ 51307-43-8 ]
[ 999-97-3 ]
2-amino-4-(trimethylsilyloxymethyl)thiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54%	Heating;

Reference： [1]Zablotskaya; Segal; Germane; Shestakova; Domracheva; Nesterova; Geronikaki; Lukevics [Chemistry of Heterocyclic Compounds, 2002, vol. 38, # 7, p. 859 - 866]

8
[ 38987-72-3 ]
[ 17356-08-0 ]
[ 51307-43-8 ]

Yield	Reaction Conditions	Operation in experiment
80%	In ethanol for 1.5h; Heating / reflux;	10; 11; 12 1-Bromo-3-hydroxypropan-2-one (60 g, 392 mmol) and thiourea (34 g, 451 mmol) were charged into a 1 L round bottom flask containing 400 mL of EtOH. The resulting mixture was heated to reflux for 90 minutes. The reaction mixture was then cooled and concentrated under reduced pressure, and a precipitate formed. The product was obtained as a solid (40 g, yield=80%) after filtration and washing three times with hexane. The product was used directly in the next step without further purification. LCMS (API-ES) m/z (%) 131.2 (100%, M++H).

Reference： [1]Current Patent Assignee: AMGEN INC - US2007/173506, 2007, A1 Location in patent: Page/Page column 34

9
[ 51307-43-8 ]
[ 394-02-5 ]
C₁₁H₈FN₃O₄S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 1357 - 1360

10
[ 51307-43-8 ]
[ 1263077-21-9 ]
[ 1263077-33-3 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate In 1,4-dioxane at 80℃;	6.B (2-aminothiazol-4-yl)methanol (70.0 mg, 0.54 mmol) and K2CO3 (148.6 mg, 1.08 mmol) were added to a solution of 5,7-dichloro-3-methylpyrido[4,3-0C overnight, cooled down, quenched with H2O (20 niL) and extracted with ethyl acetate (3 x 5 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered, concentrated, and purified by silica gel chromatography (10%methanol/dichloromethane) to give 7-chloro-5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methylpyrido[4,3-

Reference： [1]Current Patent Assignee: IRM LLC - WO2011/14795, 2011, A2 Location in patent: Page/Page column 92-93

11
[ 51307-43-8 ]
[ 677-69-0 ]
[ 1354658-61-9 ]

Yield	Reaction Conditions	Operation in experiment
79%	With sodium dithionite; sodium hydrogencarbonate In water; acetonitrile at 5 - 10℃; Inert atmosphere;	4.5. Typical procedure of the reductive polyfluoroalkylation of substituted 2-aminothiazoles General procedure: Sodium dithionite (2.0 mmol) was added in one portion to a mixture of 2-aminothiazole (1.0 mmol), NaHCO3 (2.0 mmol) and polyfluoroalkyl iodide (1.5 mmol) in 10.0 mL acetonitrile/water (3:1/v:v) at 5-10 °C under Ar atmosphere. The mixture was stirred until complete conversion of starting material as indicated by TLC or 19F NMR analysis. Acetonitrile was removed under reduced pressure and water (5 mL) was added. The mixture was extracted with ethyl acetate (4.0 mL × 3) and the combined organic layers were dried over Na2SO4. The solvent was removed under vacuum and the residue was purified by column chromatography on silica gel (petroleum/ethyl acetate) to give the product.

Reference： [1]Location in patent: experimental part Qi, Qingqing; Shen, Qilong; Lu, Long [Journal of Fluorine Chemistry, 2012, vol. 133, p. 115 - 119]

12
[ 51307-43-8 ]
1-(1-methyl-1H-tetrazol-5-yl)-2-(methylsulfonyl)-1H-benzo[d]imidazole [ No CAS ]
4-(((1-(1-methyl-1Htetrazol-5-yl)-1H-benzo[d]imidazol-2-yl)oxy)methyl)thiazol-2-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine at 110℃; for 18h; Sealed tube;	75 Example 75- 2-Cyclopentyl-N-(4-(((1-(1-methyl-IH-tetrazol-5-yl)-IH-benzo[dJimidazol-2- yl)oxy)methyl)thiazol-2-yl)acetamide 75 A solution of (2-aminothiazol-4-yl)methanol (40 mg, 0.31 mmol) and i-(i-methyl-iH-tetrazol-5- yl)-2-(methylsulfonyl)-iH-benzo[d]imidazole (40 mg, 0.14 mmol) in triethylamine (0.5 mL) was heated at 11000 in a sealed tube for i8h. The resulting brown gum was chromatographed on silica (i2g Claricep cartridge) eluting with 0-25% MeOH / DCM to give 4-(((i-(i-methyl-i Htetrazol-5-yl)-i H-benzo[d]imidazol-2-yl)oxy)methyl)thiazol-2-amine (47 mg, not pure). (Analysis of this intermediate: LCMS (method A): 1.76mm (329.0 MH), used without further purification.) A solution of this material in DCM (0.5 mL) was treated with cyclopentylacetyl chloride (0.019 mL, 0.14 mmol) and triethylamine (0.020 mL, 0.14 mmol) and stirred at RT for 18 h then was chromatographed on silica (i2g Claricep) to give an impure sample of 2-cyclopentyl-N-(4-(((i- (i-methyl-i H-tetrazol-5-yl)- 1 H-benzo[d]im idazol-2-yl)oxy) methyl)thiazol-2-yl)acetam ide 75 (15 mg) as a yellow oil. LCMS (method A): 2.71 mm (439.1 MH).

Reference： [1]Current Patent Assignee: REDAG CROP PROTECTION LTD - WO2017/178819, 2017, A1 Location in patent: Page/Page column 101; 102

13
[ 51307-43-8 ]
(trans)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxylic acid [ No CAS ]
(trans)-(2-aminothiazol-4-yl)methyl 3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxylate [ No CAS ]
(trans)-3-(2-(difluoromethoxy)-5-fluorophenoxy)-N-(4-(hydroxymethyl)thiazol-2-yl)cyclobutanecarboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 22% 2: 13%	Stage #1: (trans)-3-(2-(difluoromethoxy)-5-fluorophenoxy)cyclobutanecarboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.166667h; Stage #2: 2-amino-4-hydroxymethylthiazole In N,N-dimethyl-formamide for 18h;	14 (trans)-(2-Aminothiazol-4-yl)methyl 3-(2-(difluoromethoxy)-5- fluorophenoxy)cyclobutanecarboxylate,and(trans)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-N-(4-(hydroxymethyl)thiazol-2- yl)cyclobutanecarboxamide To a DMF (2 mL) solution of (irans)-3-(2-(difluoromethoxy)-5- fluorophenoxy)cyclobutanecarboxylic acid (Intermediate 4) (50 mg, 0.18 mmol) was added HATU (103 mg, 0.27 mmol) and /V,/V-diisopropylethylamine (0.063 mL, 0.36 mmol). After 10 minutes, (2-aminothiazol-4-yl)methanol (24 mg, 0.18 mmol) was added. The mixture was stirred for 18 h, diluted with water and MeOH, and loaded onto a semi-prep HPLC (NH4OH as modifier) to afford (trans)-(2-aminothiazol-4-yl)methyl 3-(2-(difluoromethoxy)-5- fluorophenoxy)cyclobutanecarboxylate as a white solid (16 mg, 22%) as well as trans-3-(2- (difluoromethoxy)-5-fluorophenoxy)-N-(4-(hydroxymethyl)thiazol-2-yl)cyclobutanecarboxamide (9 mg, 13%) as a white solid.(frans)-(2-Aminothiazol-4-yl)methyl 3-(2-(difluoromethoxy)-5- fluorophenoxy)cyclobutanecarboxylate 1H NMR (400 MHz, CDC ) δ 2.39-2.57 (m, 2 H), 2.71 -2.79 (m, 2 H), 3.14-3.31 (m, 1 H), 4.84-4.92 (m, 1 H), 5.02 (s, 2 H), 5.15 (br s, 2 H), 6.46 (t, J = 76 Hz, 1 H), 6.47-6.51 (m, 1 H), 6.52 (s, 1 H), 6.58-6.64 (m, 1 H), 7.1 1 (dd, J = 9, 6 Hz, 1 H); LC-MS (LC-ES) M+H = 389. (ira/7s)-3-(2-(Difluoromethoxy)-5-fluorophenoxy)-W-(4-(hydroxymethyl)thiazol-2- yl)cyclobutanecarboxamide 1H NMR (400 MHz, CDCI3) δ 2.44-2.56 (m, 2 H), 2.79-2.88 (m, 2 H), 3.21 -3.31 (m, 1 H), 4.65 (s, 2 H), 4.91 -5.05 (m, 1 H), 6.48 (t, J = 12 Hz, 1 H), 6.51 -6.56 (m, 1 H), 6.59-6.68 (m, 1 H), 6.83 (s, 1 H), 7.13 (dd, J = 9, 6 Hz, 1 H); LC-MS (LC-ES) M+H = 389.

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2018/69863, 2018, A1 Location in patent: Page/Page column 280-281

14
[ 51307-43-8 ]
(trans)-3-(quinolin-8-yloxy)cyclobutanecarboxylic acid [ No CAS ]
(trans)-N-(4-(hydroxymethyl)thiazol-2-yl)-3-(quinolin-8-yloxy)cyclobutanecarboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
19%	Stage #1: (trans)-3-(quinolin-8-yloxy)cyclobutanecarboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 0.0833333h; Stage #2: 2-amino-4-hydroxymethylthiazole In N,N-dimethyl-formamide for 3h;	215 To a DMF (3 mL) solution of (frans)-3-(quinolin-8-yloxy)cyclobutanecarboxylic acid (Intermediate 79) (80 mg, 0.33 mmol) was added HATU (150 mg, 0.395 mmol) and N,N- diisopropylethylamine (0.17 mL, 1 .0 mmol). After 5 minutes, (2-aminothiazol-4-yl)methanol (51 mg, 0.40 mmol) was added, and the mixture was stirred for 3 h, quenched with water, extracted with EtOAc, dried over Na2SC>4, filtered and concentrated. The residue was purified on silica gel, eluting with a 0%-100% EtOAc:EtOH (3:1)-hexanes gradient to give the title compound (30 mg, 19%). 1H NMR (400 MHz, CD3SOCD3) δ 2.49-2.53 (m, 2 H), 2.72-2.81 (m, 2 H), 3.44 (tt, J = 10, 5 Hz, 1 H), 4.43 (d, J = 1 Hz, 2 H), 5.08-5.16 (m, 1 H), 6.88-6.91 (m, 1 H), 7.1 1 -7.18 (m, 1 H), 7.51 -7.60 (m, 3 H), 7.71 -7.79 (m, 1 H), 8.59-8.69 (m, 1 H), 8.92-8.97 (m, 1 H), 12.10 (s, 1 H); LC-MS (LC-ES) M+H = 356.

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2018/69863, 2018, A1 Location in patent: Page/Page column 409

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P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 51307-43-8 ] {[proInfo.proName]}

Quality Control of [ 51307-43-8 ]

Related Doc. of [ 51307-43-8 ]

Product Details of [ 51307-43-8 ]

Calculated chemistry of [ 51307-43-8 ]

Physicochemical Properties

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Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 51307-43-8 ]

Application In Synthesis of [ 51307-43-8 ]

[ 51307-43-8 ] Synthesis Path-Upstream 1~5

[ 51307-43-8 ] Synthesis Path-Downstream 1~14

Related Functional Groups of [ 51307-43-8 ]

Alcohols

Amines

Related Parent Nucleus of [ 51307-43-8 ]

Thiazoles

Precautionary Statements-General

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Physical hazards

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Inquiry

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[ 51307-43-8 ]

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[ 51307-43-8 ]