Home Chemistry Heterocyclic Building Blocks Pyridines (3-Bromopyridin-2-Yl)Methanol
Substitution Reactions: The bromine atom can undergo substitution reactions, where it is replaced by another functional group. For example, it can undergo nucleophilic substitution reactions to form other alkyl halides or aryl halides.
Oxidation: The alcohol group can be oxidized to form an aldehyde or a carboxylic acid, depending on the conditions of the reaction. This can be achieved using oxidizing agents like chromic acid (CrO3/H2SO4), potassium permanganate (KMnO4), or Jones reagent (CrO3/H2SO4 in acetone).
Esterification: The alcohol group can react with carboxylic acids or acid derivatives (such as acyl chlorides) to form esters. This reaction typically requires a catalyst like sulfuric acid.
Dehydration: Under acidic conditions, the alcohol group can undergo dehydration to form an alkene. This typically involves the removal of a water molecule from adjacent carbon atoms.
Grignard Reaction: The compound can undergo reactions with Grignard reagents to form new carbon-carbon bonds. This can be useful in synthesizing more complex molecules.
Nucleophilic Addition: The pyridine ring can undergo nucleophilic addition reactions with electrophiles, adding onto the aromatic ring.
Reduction: The compound can be reduced to different products, depending on the reagent and conditions used. For instance, reduction of the bromine atom can yield an alkyl group, and reduction of the hydroxyl group can yield an alkane.
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