Home Chemistry Organic Building Blocks Fluorinated Building Blocks (3-Fluorophenyl)Boronic Acid
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—B(OH)2).
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Formation of 【esters|https://www.ambeed.com/esters.html】 and 【Amides|https://www.ambeed.com/amides.html】: Phenylboronic acid can react with 【alcohols|https://www.ambeed.com/alcohols.html】 or 【amines|https://www.ambeed.com/amines.html】 to form 【esters|https://www.ambeed.com/esters.html】 and 【amides|https://www.ambeed.com/amides.html】, respectively, under appropriate conditions.
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(5-Fluoro-2-(hydroxymethyl)phenyl)boronic acid
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5-Fluoro-2-(trifluoromethyl)phenylboronic acid
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2-Methoxycarbonyl-5-fluorophenylboronic acid
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(5-Fluoro-2-(methoxymethoxy)phenyl)boronic acid
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(5-Fluoro-2-(methylcarbamoyl)phenyl)boronic acid
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(2-(Ethoxycarbonyl)-5-fluorophenyl)boronic acid
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(3-Fluoro-5-(methoxycarbonyl)-2-methylphenyl)boronic acid
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(2,3-Difluoro-4-isopropoxyphenyl)boronic acid
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(2,3-Difluoro-4-propoxyphenyl)boronic acid
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