Home Chemistry Heterocyclic Building Blocks Pyridines (5-(Trifluoromethyl)Pyridin-3-Yl)Boronic Acid
Suzuki-Miyaura Coupling: This reaction involves the cross-coupling of an aryl- or vinyl-boronic acid with an aryl- or vinyl-halide catalyzed by a palladium catalyst. It's widely used for the synthesis of biaryl compounds and functionalized olefins.
Borylation Reactions: Boronic acids can undergo borylation reactions with various electrophiles such as halides, triflates, and epoxides. These reactions are useful for introducing boron functionality into organic molecules.
Hydroboration: Boronic acids can undergo hydroboration reactions with alkenes or alkynes in the presence of borane reagents. This reaction leads to anti-Markovnikov hydration of alkenes to form alkylboranes.
Suzuki-Miyaura Cross-Coupling: This is a palladium-catalyzed cross-coupling reaction between an aryl halide or pseudohalide and an organoboron compound. It's widely used in the synthesis of pharmaceuticals, agrochemicals, and materials science.
Boronic ester Formation: Boronic acids can react with alcohols in the presence of a suitable base to form boronic esters. These esters are important intermediates in organic synthesis, particularly in Suzuki-Miyaura reactions.
Oxidation Reactions: Boronic acids can be oxidized to their corresponding boronic acid derivatives, such as boronic acids to boronic acids and boronate esters to phenols, using various oxidizing agents.
Reduction Reactions: Boronic acids can undergo reduction to boronic acid derivatives using reducing agents such as sodium borohydride or lithium aluminum hydride.
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(2-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)boronic acid
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(6-Methyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid
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(2-Isopropoxy-5-(trifluoromethyl)pyridin-3-yl)boronic acid
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(5-(Trifluoromethyl)pyridin-3-yl)boronic acid
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