Home Chemistry Heterocyclic Building Blocks Oxadiazoles 1,3,4-Oxadiazole
Nucleophilic Substitution: The oxygen and nitrogen atoms in the oxadiazole ring can act as nucleophiles in certain conditions, leading to substitution reactions.
Electrophilic Substitution: Under appropriate conditions, 1,3,4-oxadiazole can undergo electrophilic aromatic substitution reactions. This involves the attack of an electrophile on the ring.
Ring Opening Reactions: Depending on the conditions and reagents, 1,3,4-oxadiazole can undergo ring-opening reactions to form open-chain compounds.
Cyclization Reactions: 1,3,4-oxadiazole can serve as a precursor in the synthesis of various heterocyclic compounds. It can undergo cyclization reactions to form more complex ring systems.
Reduction Reactions: The nitrogen and oxygen atoms in the oxadiazole ring can be reduced under appropriate conditions, resulting in the formation of different compounds.
Oxidation Reactions: 1,3,4-oxadiazole can be oxidized to form different products, depending on the reagents and conditions used.
Condensation Reactions: 1,3,4-oxadiazole can participate in condensation reactions with appropriate reagents to form more complex compounds.
Functional Group Transformations: Various functional groups can be introduced or modified on the 1,3,4-oxadiazole ring through a variety of synthetic reactions.
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Methyl 5-methyl-1,3,4-oxadiazole-2-carboxylate
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2-(5-Methyl-1,3,4-oxadiazol-2-yl)acetonitrile
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Methyl 5-tert-butyl-1,3,4-oxadiazole-2-carboxylate
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Ethyl 5-(tert-butyl)-1,3,4-oxadiazole-2-carboxylate
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Potassium 5-methyl-1,3,4-oxadiazole-2-carboxylate
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Ethyl 5-(aminomethyl)-1,3,4-oxadiazole-2-carboxylate 2,2,2-trifluoroacetate
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Ethyl 5-(((tert-butoxycarbonyl)amino)methyl)-1,3,4-oxadiazole-2-carboxylate
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(S)-tert-Butyl (1-(5-mercapto-1,3,4-oxadiazol-2-yl)ethyl)carbamate
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2-(Chloromethyl)-5-methyl-1,3,4-oxadiazole
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5-Methyl-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester
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Ethyl 5-amino-1,3,4-oxadiazole-2-carboxylate
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