Home Chemistry Organic Building Blocks Chlorides 1,3-Dichloro-2-Fluorobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Cl,—F).
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
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1,3-Dichloro-2-fluoro-5-(trifluoromethyl)benzene
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3,5-Dichloro-4-fluorophenylboronic acid
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1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
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