Chemistry Organic Building Blocks Aryls 1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One

1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One

These compounds have the same murcko framework: 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

Michael Addition: Chalcones are known to undergo Michael addition reactions with nucleophiles. The β-unsaturated carbonyl group is reactive and can react with nucleophiles such as amines or thiols.
Enolization: The α,β-unsaturated carbonyl system allows for tautomerization and enolization reactions under certain conditions. This can be important in reactions involving nucleophiles or in reactions leading to the formation of other functional groups.
Condensation Reactions: The carbonyl group in the chalcone structure can participate in condensation reactions with a variety of nucleophiles, leading to the formation of new carbon-carbon or carbon-heteroatom bonds.
Aldol Condensation: Chalcones can undergo aldol condensation reactions, where two molecules of the chalcone or another carbonyl compound react to form a β-hydroxy ketone.
Reduction: The carbonyl group can be reduced to the corresponding alcohol using reducing agents.
Oxidation: The phenolic hydroxyl group or the α,β-unsaturated carbonyl system may be susceptible to oxidation under certain conditions.
Cyclization: Depending on the reaction conditions and the presence of suitable functional groups, cyclization reactions could occur.
Substitution Reactions: The phenyl groups can participate in electrophilic aromatic substitution reactions under appropriate conditions.

Further Reading:

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((2S,6S)-6-Phenoxytetrahydro-2H-Pyran-2-Yl)Methanol (2S,4S)-2-Phenoxytetrahydro-2H-Pyran-4-Yl Acetate (6-Phenoxytetrahydro-2H-Pyran-2-Yl)Methanol (8S,9S,14R)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-3H-Cyclopenta[A]Phenanthren-3-One (8S,9S,14R)-7,8,9,11,12,13,14,15,16,17-Decahydro-6H-Cyclopenta[A]Phenanthrene (9H-Fluoren-9-Yl)Methyl (2-(Tritylthio)Ethyl)Carbamate (9H-Fluoren-9-Yl)Methyl Cyclohexylcarbamate (Benzylsulfonyl)Benzene (Cyclopentyloxy)Benzene (E)-1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One (E)-3-Styrylphenol 1,1-Dimethylcyclopropane 1,2-Bis(Diphenylphosphaneyl)Ethane 1,3,4,5-Tetrahydro-2H-Benzo[B]Azepin-2-One 1,3-Diphenylurea 1-(2-Hydroxyphenyl)-2-Phenylethan-1-One 1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One 1-([1,1'-Biphenyl]-4-Yl)Ethan-1-One 1-(Naphthalen-2-Yl)Ethan-1-One 1-Benzyl-4-Chlorobenzene 1-Benzyl-4-Fluorobenzene 1-Bromonaphthalene 1-Chloronaphthalene 1-Fluoronaphthalene 1-Methoxynaphthalene 1-Methyl-4-(Phenylethynyl)Benzene 1-Methylnaphthalene 1-Naphthaldehyde 1-Naphthoic Acid 1-Nitronaphthalene 10H-Phenothiazine 2,2',3,3',5,5',6,6'-Octafluoro-1,1'-Biphenyl 2,5-Diphenylthiophene 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol 2-(Trifluoromethyl)-1,1'-Biphenyl 2-Benzylaniline 2-Bromo-1,1'-Biphenyl 2-Bromonaphthalene 2-Chloro-1,1'-Biphenyl 2-Chloronaphthalene 2-Ethoxynaphthalene 2-Fluorocyclopropane-1-Carboxylic Acid 2-Hydroxycyclohexa-2,5-Diene-1,4-Dione 2-Iodonaphthalene 2-Methoxy-1,1'-Biphenyl 2-Methoxynaphthalene 2-Methoxytetrahydro-2H-Pyran 2-Methyl-1,1'-Biphenyl 2-Methylnaphthalene 2-Naphthaldehyde 2-Naphthoic Acid 2-Naphthonitrile 2-Nitronaphthalene 2-Phenoxytetrahydro-2H-Pyran-4-Yl Acetate 2-Phenylnaphthalene 3,3'-Diphenyl-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthalene 3,3-Diphenyl-3H-Benzo[C][1,2]Oxathiole 1,1-Dioxide 3-Bromo-1,1'-Biphenyl 3-Chloro-1,1'-Biphenyl 3-Fluoro-1,1'-Biphenyl 3-Methyl-1,1'-Biphenyl 3-Methyl-1,1':4',1''-Terphenyl 3-Phenethylphenol 3-Phenyl-1,2,4,5-Tetrazine 3-Styrylphenol 4-(Bromomethyl)-1,1'-Biphenyl 4-(Phenyldiazenyl)Benzoic Acid 4-(Phenylsulfonyl)Morpholine 4-(Tert-Butyl)-1,1'-Biphenyl 4-Cyclohexylphenol 4-Iodo-1,1'-Biphenyl 4-Methoxy-1,1'-Biphenyl 9H-Xanthene [1,1'-Biphenyl]-2-Amine [1,1'-Biphenyl]-2-Carbonitrile [1,1'-Biphenyl]-2-Carboxylic Acid [1,1'-Biphenyl]-2-Ol [1,1'-Biphenyl]-3-Amine [1,1'-Biphenyl]-3-Carbaldehyde [1,1'-Biphenyl]-3-Carboxylic Acid [1,1'-Biphenyl]-3-Ol [1,1'-Biphenyl]-4-Carbaldehyde [1,1'-Biphenyl]-4-Carbonitrile [1,1'-Biphenyl]-4-Ol [1,1'-Biphenyl]-4-Ylboronic Acid Benzyltriphenylphosphonium Cyclopentylbenzene Cyclopropanecarboxylic Acid Cyclopropyl(Phenyl)Methanamine Cyclopropyl(Phenyl)Methanone Diphenyl Phosphonate Diphenylphosphane Diphenylphosphine Oxide Ethane-1,1-Diyldibenzene Ethene-1,1,2-Triyltribenzene Ethyl Cyclopropanecarboxylate Methyl 1-Naphthoate Methyl 2-Naphthoate Methyl [1,1'-Biphenyl]-4-Carboxylate Methyl Cyclopropanecarboxylate N,1-Diphenylmethanimine N,N-Dimethylnaphthalen-1-Amine N-((5R,6R)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptan-6-Yl)-2-Phenylacetamide N-Benzylbenzamide N-Benzylbenzenesulfonamide N-Cyclopropylbenzamide N-Cyclopropylbenzenesulfonamide N-Phenethylbenzamide N-Phenyl-2-Naphthamide Naphthalen-1-Ol Naphthalen-1-Ylboronic Acid Naphthalen-1-Ylmethanol Naphthalen-2-Amine Naphthalen-2-Ol Naphthalen-2-Ylboronic Acid Naphthalene-1,4-Diol Naphthalene-2-Sulfonic Acid Propane-2,2-Diyldibenzene Tert-Butyl Cyclopropylcarbamate Tetrahydro-2H-Pyran-2-Ol Tetrahydro-2H-Pyran-2-Yl Acetate Tetraphenylmethane Triphenylene Vinylcyclopropane

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