Home Chemistry Organic Building Blocks Benzyl Chlorides 1-(Chloromethyl)-3-Fluorobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —CH2Cl,—F).
SN1 Reaction: Chloromethylbenzene can undergo SN1 nucleophilic substitution reactions with nucleophiles, where the chloromethyl group is replaced by a nucleophilic group. The reaction proceeds via a carbocation intermediate.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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3-Fluoro-4-(trifluoromethyl)benzyl chloride
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