Chemistry Heterocyclic Building Blocks Piperidines 1-(Methylsulfonyl)Piperidine

1-(Methylsulfonyl)Piperidine

These compounds have the same murcko framework: 1-(methylsulfonyl)piperidine

Nucleophilic Substitution: The sulfonyl group can undergo nucleophilic substitution reactions with various nucleophiles, leading to the displacement of the sulfonyl group.
Reduction: The sulfonyl group can be reduced to the corresponding sulfide or the amine using reducing agents such as sodium borohydride or hydrogen gas over a metal catalyst.
Substitution Reactions: The piperidine ring can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution.
Alkylation: The nitrogen atom in the piperidine ring can be alkylated by reaction with alkyl halides or sulfonates.
Acylation: The nitrogen atom in the piperidine ring can undergo acylation reactions to form N-acyl derivatives.
Ring-opening Reactions: The piperidine ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Hydrolysis: The sulfonyl group can undergo hydrolysis under acidic or basic conditions to form the corresponding alcohols and sulfonic acids.

Further Reading:

Framework+−

(9H-Fluoren-9-Yl)Methyl Piperidine-1-Carboxylate (E)-N-(3-Oxo-1-Phenyl-3-(Piperidin-1-Yl)Prop-1-En-2-Yl)Benzamide (R)-2-Phenylpiperidine (R)-3-Aminopiperidin-2-One (R)-N-(Piperidin-3-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (S)-2-Phenylpiperidine (S)-N-Phenylpiperidine-2-Carboxamide 1,3-Dihydrospiro[Indene-2,4'-Piperidine] 1,4'-Bipiperidine 1-((Benzyloxy)Carbonyl)Piperidine-2-Carboxylic Acid 1-((Benzyloxy)Carbonyl)Piperidine-3-Carboxylic Acid 1-(Methylsulfonyl)Piperidine 1-(Phenylsulfonyl)Piperidine 1-(Piperidin-1-Yl)Ethan-1-One 1-(Piperidin-4-Yl)Piperazine 1-Benzyl 3-Methyl Piperidine-1,3-Dicarboxylate 1-Benzyl-N-Methylpiperidin-3-Amine 1-Benzylpiperidin-3-One 1-Benzylpiperidin-4-Amine 1-Benzylpiperidin-4-One 1-Isopropylpiperidine 1-Methyl-4-Phenylpiperidine 1-Methylpiperidin-2-One 1-Oxa-8-Azaspiro[4.5]Decane 1-Phenylpiperidin-2-One 2,2-Dimethylpiperidin-4-One 2,2-Dimethylpiperidine 2,7-Diazaspiro[3.5]Nonane 2,8-Diazaspiro[4.5]Decan-3-One 2,8-Diazaspiro[4.5]Decane 2-(Piperidin-1-Yl)Ethan-1-Amine 2-(Piperidin-1-Yl)Ethan-1-Ol 2-(Piperidin-1-Yl)Pyridine 2-(Piperidin-1-Yl)Pyrimidine 2-(Piperidin-2-Yl)Ethan-1-Ol 2-(Piperidin-4-Yl)Ethan-1-Ol 2-(Piperidin-4-Yl)Pyridine 2-Methylpiperidin-4-One 2-Methylpiperidine 2-Phenylpiperidine 3,3-Difluoropiperidin-4-One 3,3-Difluoropiperidine 3,3-Dimethylpiperidin-4-One 3,3-Dimethylpiperidine 3-(1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione 3-(Piperidin-1-Yl)Pyridine 3-(Piperidin-4-Yl)-1H-Indazole 3-(Piperidin-4-Yl)-1H-Indole 3-(Piperidin-4-Yl)Pyridine 3-Fluoropiperidin-4-One 3-Fluoropiperidine 3-Methoxypiperidine 3-Methylpiperidin-4-One 3-Methylpiperidine 3-Phenylpiperidine 4,4-Difluoropiperidine 4-(1H-Pyrazol-1-Yl)Piperidine 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine 4-(Azetidin-1-Yl)Piperidine 4-(Benzyloxy)Piperidine 4-(Piperidin-1-Yl)Pyrimidine 4-(Pyrrolidin-1-Yl)Piperidine 4-Benzylpiperidine 4-Hydrazineylpiperidine 4-Hydroxypiperidin-2-One 4-Methyl-1-Phenylpiperidine 4-Methylenepiperidine 4-Oxopiperidine-2-Carboxylic Acid 4-Phenylpiperidin-4-Ol 5-Hydroxypiperidin-2-One 6-Azaspiro[2.5]Octane 6-Oxopiperidine-2-Carboxylic Acid 7-Azaspiro[3.5]Nonane Azepane Benzyl (R)-3-Aminopiperidine-1-Carboxylate Benzyl 3-Hydroxypiperidine-1-Carboxylate Benzyl 4-Oxopiperidine-1-Carboxylate Benzyl Piperidin-4-Ylcarbamate Benzyl Piperidine-1-Carboxylate Benzyl-3-Aminopiperidine-1-Carboxylate Ethyl Piperidine-1-Carboxylate Ethyl Piperidine-2-Carboxylate Ethyl Piperidine-3-Carboxylate Ethyl Piperidine-4-Carboxylate Methyl 4-Oxopiperidine-2-Carboxylate Methyl Piperidine-2-Carboxylate Methyl Piperidine-3-Carboxylate N-Benzylpiperidin-4-Amine N-Methylpiperidin-3-Amine N-Phenylpiperidin-4-Amine N-Phenylpiperidine-2-Carboxamide Phenyl(Piperidin-1-Yl)Methanone Phenyl(Piperidin-4-Yl)Methanone Piperidin-2-Ylmethanamine Piperidin-2-Ylmethanol Piperidin-3-Amine Piperidin-3-Ol Piperidin-3-One Piperidin-3-Ylmethanamine Piperidin-3-Ylmethanol Piperidin-4-Amine Piperidin-4-Ol Piperidin-4-Ylmethanamine Piperidin-4-Ylmethanol Piperidine-2,4-Dione Piperidine-2,6-Dione Piperidine-2-Carboxylic Acid Piperidine-3-Carboxamide Piperidine-3-Carboxylic Acid Piperidine-4-Carboxylic Acid Quinuclidine Spiro[Benzo[D][1,3]Oxazine-4,4'-Piperidin]-2(1H)-One Spiro[Chromane-2,4'-Piperidin]-4-One Spiro[Indene-2,4'-Piperidin]-1(3H)-One Spiro[Indoline-3,4'-Piperidin]-2-One Spiro[Indoline-3,4'-Piperidine] Tert-Butyl (2-Oxopiperidin-3-Yl)Carbamate Tert-Butyl (6-Oxopiperidin-3-Yl)Carbamate Tert-Butyl (Piperidin-3-Ylmethyl)Carbamate Tert-Butyl 2-Oxopiperidine-1-Carboxylate Tert-Butyl 3-Bromopiperidine-1-Carboxylate Tert-Butyl 4-Oxopiperidine-1-Carboxylate Tert-Butyl 4-Phenoxypiperidine-1-Carboxylate Tert-Butyl 4-Phenylpiperidine-1-Carboxylate Tert-Butyl Piperidin-3-Ylcarbamate

By Key Group+−

Acetylpiperidine Aminopiperidine Benzoylpiperidine Benzylpiperidine Bipiperidine Boc-Piperidine Boronate-Piperidine-Carboxylate Bromopiperidine Carbamoylpiperidine Chloropiperidine Cyanopiperidine Cyclopropylpiperidin Difluoromethyl-Piperidine Difluoropiperidine Dimethylpiperidine Dioxaborolane-Piperidine Dioxopiperidine Ethylpiperidine Ethynylpiperidine Fluoropiperidine Formylpiperidine Hydroxyethyl-Piperidine-Carboxylate Hydroxymethyl-Piperidine-Carboxylate Hydroxypiperidine Indazole-Piperidine-Carboxylate Indoline-Piperidine Isopropylpiperidine Methoxypiperidine Methylenepiperidine Methylpiperidine Oxoethyl-Piperidine-Carboxylate Oxopiperidine Pentamethylpiperidin Phenoxypiperidine Phenyl-Sulfonyl-Piperidine Phenylpiperidine Piperidin-Amine Piperidin-Imidazolyl Piperidine-Benzimidazole Piperidine-Benzofuran Piperidine-Carboxylate Piperidine-Carboxylate-Hydrochloride Piperidine-Carboxylic Acid Piperidine-Ethanol Piperidine-Hydrochloride Piperidine-Indole Piperidine-Methanamine Piperidine-Methanone Piperidine-Nitrile Piperidine-Piperidine Piperidine-Propanol Piperidine-Pyrimidine Piperidine-Triazole Piperidineacetic Piperidinecarboxylate Piperidinecarboxylic Piperidinemethanol Piperidinone Piperidinyl-Phenyl-Boronic Acid Piperidinyl-Phenyl-Boronic Acid/Ester Piperidinyl-Phenyl-Boronic-Acid Propylpiperidine Pyrazole-Piperidine Pyridin-Piperidine Spiro-Benzofuran-Piperidine Tetrahydropyrazolopyridine Tetramethylpiperidine Trifluoromethyl-Phenyl-Piperidine Trifluoromethyl-Piperidine

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Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzisoxazoles Benzofurans Benzoxazoles Dioxolanes Epoxides Furans Guanidines Imidazoles Imidazolidines Imidazolines Indazoles Indoles Indolines Isoxazoles Morpholines Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxadiazoles Oxazines Oxazolidines Oxazolines Oxetanes Piperazines Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrrolidines Quinazolines Spiroes Tetrahydrofurans Tetrahydroisoquinolines Tetrahydropyrans Thiophenes Triazoles

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Acyl Chlorides Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Azoes Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Hydroxylamines Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Thioureas Trifluoromethyls Ureas

Heterocyclic related+−

Metal Catalysts Piperidines

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