Home Chemistry Organic Building Blocks Bromides 1-Bromo-2-Chloro-3-Methylbenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—Cl,—CH3).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Sandmeyer Reaction: Chlorobenzene can be converted to other aryl halides through the Sandmeyer reaction, involving replacement of the chlorine atom with other halogens.
Halogenation: Toluene can undergo halogenation reactions with halogens (such as chlorine or bromine) in the presence of a catalyst or under UV light. The hydrogen atoms on the benzene ring can be replaced by halogen atoms, resulting in the formation of mono-, di-, or polyhalogenated derivatives of toluene.
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N-(4-Bromo-3-chloro-2-methylphenyl)acetamide
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(5-Bromo-4-chloro-2-fluoro-3-methylphenyl)boronic acid
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1-Bromo-2-chloro-5-fluoro-3-methylbenzene
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