Home Chemistry Organic Building Blocks Bromides 1-Bromo-2-Fluoro-4-Nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—NO2).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Reduction: The nitro group in nitrobenzene can be reduced to an amino group (-NH2) using reducing agents like iron and hydrochloric acid, or more commonly, using catalytic hydrogenation. This reaction produces aniline.
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1-Bromo-2-fluoro-5-methyl-4-nitrobenzene
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1-Bromo-2-fluoro-5-methoxy-4-nitrobenzene
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(5-Bromo-4-fluoro-2-nitro-phenyl)-methyl-amine
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1-Bromo-2-fluoro-4-nitro-5-(trifluoromethyl)benzene
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