Home Chemistry Heterocyclic Building Blocks Indazoles 1H-Indazole-3-Carboxylic Acid
Substitution Reactions: The carboxylic acid group can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution.
Esterification: The carboxylic acid group can react with alcohols to form esters under acidic or basic conditions.
Amide Formation: The carboxylic acid group can react with amines to form amides under appropriate conditions.
Decarboxylation: Under certain conditions, such as heating or treatment with specific reagents, decarboxylation may occur, leading to the loss of the carboxyl group and formation of the corresponding indazole derivative.
Reduction: The carboxylic acid group can be reduced to the corresponding alcohol using reducing agents such as lithium aluminum hydride or sodium borohydride.
Oxidation: The indazoles moiety can be oxidized to form various oxidized derivatives under suitable conditions.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Ring-closure Reactions: The carboxylic acid group can undergo ring-closure reactions under certain conditions, leading to the formation of cyclic compounds or fused ring systems
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5-Bromo-1-methyl-1H-indazole-3-carboxylic acid
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5-Bromo-6-chloro-1H-indazole-3-carboxylic acid
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4,6-Dibromo-1H-indazole-3-carboxylic acid
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6-Methoxy-1H-indazole-3-carboxylic acid
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6-(Trifluoromethyl)-1H-indazole-3-carboxylic acid
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6-(Methoxycarbonyl)-1H-indazole-3-carboxylic acid
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1-Methyl-6-nitro-1H-indazole-3-carboxylic acid
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