Home Chemistry Organic Building Blocks Alkenyls 2-Benzalacetophenone
Aldol condensation: 2-Benzalacetophenone can undergo aldol condensation reactions to form α,β-unsaturated ketones. This reaction typically involves the removal of a proton from the α-carbon and the β-carbon, followed by the formation of a new carbon-carbon bond. This can lead to the formation of a conjugated enone.
Grignard reaction: 2-Benzalacetophenone can react with a Grignard reagent (such as phenylmagnesium bromide) to form an alcohol after protonation. This reaction can be used for the synthesis of various compounds.
Reduction: Reduction reactions can be carried out on the carbonyl group of 2-Benzalacetophenone to yield the corresponding alcohol. Common reducing agents used for this purpose include sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Friedel-Crafts acylation: 2-Benzalacetophenone can be acylated through a Friedel-Crafts acylation reaction with acyl halides or anhydrides in the presence of a Lewis acid catalyst (typically aluminum chloride, AlCl3).
Oxidation: 2-Benzalacetophenone can be oxidized to the corresponding carboxylic acid or other oxidized products using various oxidizing agents like potassium permanganate (KMnO4) or Jones reagent.
Nucleophilic addition reactions: Depending on the conditions and the nucleophiles used, nucleophilic addition reactions can occur at the carbonyl group of 2-Benzalacetophenone, leading to various products.
Wittig reaction: 2-Benzalacetophenone can be converted to an α,β-unsaturated ketone using a Wittig reaction. This reaction involves the use of a phosphonium ylide and is a powerful method for introducing double bonds into the molecule.
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(E)-3-(4-Methoxyphenyl)-1-phenylprop-2-en-1-one
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(E)-3-(2-Hydroxyphenyl)-1-phenylprop-2-en-1-one
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3-(4-(Dimethylamino)phenyl)-1-(4-fluorophenyl)prop-2-en-1-one
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3-(3-(4-Hydroxyphenyl)-3-oxoprop-1-en-1-yl)benzonitrile
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(E)-1-(4-Fluorophenyl)-3-phenylprop-2-en-1-one
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1-(4-Chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
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