Home Chemistry Heterocyclic Building Blocks Pyridines 2-Bromopyridin-3-Amine
Substitution Reactions: The bromine atom can be substituted with other nucleophiles, such as amines, alcohols, or thiols, via nucleophilic substitution reactions. This can yield a variety of products depending on the reagents and reaction conditions.
Reductive Amination: The amine group can undergo reductive amination reactions, where it reacts with carbonyl compounds (such as aldehydes or ketones) in the presence of a reducing agent to form secondary or tertiary amines.
Cross-Coupling Reactions: The bromine atom can participate in palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, or Sonogashira reactions, to form carbon-carbon or carbon-heteroatom bonds with various coupling partners.
Amination Reactions: The bromine atom can be replaced with an amine group through various amination reactions, such as Buchwald-Hartwig amination, to yield different substituted pyridine derivatives.
Nucleophilic Aromatic Substitution: The amine group can serve as a nucleophile in nucleophilic aromatic substitution reactions, where it substitutes a leaving group on the pyridine ring.
Halogenation Reactions: The pyridine ring can undergo halogenation reactions, such as bromination or chlorination, at positions adjacent to the amine group, depending on the reaction conditions and reagents used.
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2-Bromo-N4-methylpyridine-3,4-diamine
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