Home Chemistry Organic Building Blocks Phenols 2-Chloro-4-Nitrophenol
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—OH,—NO2).
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Fries Rearrangement: Phenol can undergo the Fries rearrangement when treated with a Lewis acid catalyst, leading to the migration of an acyl group within the molecule.
Nitration: Nitrobenzene can undergo nitration reactions, where a nitro group (-NO2) is introduced onto the benzene ring. This is typically achieved by treating nitrobenzene with a mixture of concentrated sulfuric acid and concentrated nitric acid.
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