Chemistry Organic Building Blocks Amides 2-Hydroxybenzamide

2-Hydroxybenzamide

These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —C(O)NH2,—OH).

Friedel-Crafts Acylation: Benzamide can be acylated using Friedel-Crafts acylation reactions. This involves the substitution of a hydrogen atom on the benzene ring with an acyl group from an 【acyl chloride|https://www.ambeed.com/acyl-chlorides.html】 or an 【acid anhydride|https://www.ambeed.com/Anhydrides.html】 in the presence of a Lewis acid catalyst.
Fries Rearrangement: Phenol can undergo the Fries rearrangement when treated with a Lewis acid catalyst, leading to the migration of an acyl group within the molecule.

Further Reading:

Framework+−

(3-(Phenylcarbamoyl)Phenyl)Boronic Acid (4-(Phenylcarbamoyl)Phenyl)Boronic Acid (9H-Fluoren-9-Yl)Methyl (3-Phenylpropyl)Carbamate (S)-N-Phenethyl-3-(Pyrrolidin-2-Yl)Propanamide (S)-N-Phenylpiperidine-2-Carboxamide 1-(Pyridin-2-Yl-L2-Azaneyl)Ethan-1-One 1-Methylindoline-2,3-Dione 1-Phenylurea 1H-Pyrazole-5-Carboxamide 2,2-Dimethyl-1-(Pyridin-2-Yl-L2-Azaneyl)Propan-1-One 2-((Tert-Butoxycarbonyl)Amino)Benzoic Acid 2-(Trifluoromethyl)Benzamide 2-Amino-3-Phenylpropanamide 2-Amino-N-Phenylbenzamide 2-Aminobenzamide 2-Bromo-N-Phenylacetamide 2-Chloro-N-Phenylacetamide 2-Chloro-N-Phenylbenzamide 2-Chlorobenzamide 2-Fluoro-N-Methylbenzamide 2-Fluorobenzamide 2-Hydroxy-N-Phenylbenzamide 2-Hydroxybenzamide 2-Iodobenzamide 2-Methoxybenzamide 3-Benzamidopropanoic Acid 3-Bromo-4-Fluorobenzamide 3-Fluorobenzamide 3-Nitrobenzamide 3-Oxo-N-Phenylbutanamide 4-Amino-N-Phenylbenzamide 4-Benzamidobenzoic Acid 4-Fluorobenzamide 4-Oxo-4-(Phenylamino)Butanoic Acid Benzoylglycine Benzyl Benzylcarbamate Benzyl Cyclohexylcarbamate Benzyl Phenylcarbamate Ethyl 2-Oxo-2-(Phenylamino)Acetate Isonicotinamide N,N-Diethylbenzamide N,N-Dimethylbenzamide N-((5R,6R)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptan-6-Yl)-3-Phenylisoxazole-4-Carboxamide N-((6R,7R)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-Phenylacetamide N-(2-(1H-Indol-3-Yl)Ethyl)Acetamide N-(2-Benzoylphenyl)-2-Bromoacetamide N-(2-Chlorophenyl)Acetamide N-(2-Iodophenyl)Acetamide N-(2-Nitrophenyl)Acetamide N-(3-Fluorophenyl)Acetamide N-(4-Aminophenyl)Benzamide N-(4-Chlorophenyl)Acetamide N-(4-Chlorophenyl)Benzamide N-(4-Fluorophenyl)Benzamide N-(4-Phenoxyphenyl)Acetamide N-(O-Tolyl)Benzamide N-(P-Tolyl)Benzamide N-(Thiazol-2-Yl)Acetamide N-Isopropylbenzamide N-Methoxy-N-Methylbenzamide N-Methylbenzamide N-Methylpicolinamide N-Phenylacrylamide N-Phenylpivalamide Nicotinamide Phenyl Dimethylcarbamate Phenyl Ethyl(Methyl)Carbamate Picolinamide Piperidine-3-Carboxamide Pyrazine-2-Carboxamide Pyrrolidine-2-Carboxamide Tert-Butyl (1-Phenylethyl)Carbamate Tert-Butyl (4-Fluorophenyl)Carbamate Tert-Butyl (R)-Cyclopent-2-En-1-Ylcarbamate Tert-Butyl Benzylcarbamate Tert-Butyl Methyl(Phenyl)Carbamate Tert-Butyl O-Tolylcarbamate Tert-Butyl Phenethylcarbamate Tert-Butyl-Cyclopent-2-En-1-Ylcarbamate Thiophene-3-Carboxamide

By Key Group+−

(S)-2-Amino-Propanamide (S)-Methyl 3-Amino-Propanoate 2,2,2-Trifluoroacetamido 2-Acetamide 2-Acetamido-Propanoic Acid 2-Amino-Acetamide 2-Bromo-Acetamide 2-Chloro-N-Acetamide 2-Chloro-N-Methyl-Acetamide 2-Chloro-N-Methylacetamide 2-Propyn-1-Ylcarbamoyl 3-Chloro-Propanamide 3-Oxobutanamide 4-Amino-4-Oxobutanoic Acid Acetamide Acetamide Acetamido Acetamidomethyl Acrylamide Amino-2-Oxoacetic Acid Amino-Benzamide Amino-Hydroxypropanamide-Hydrochloride Benzamide Benzothioamide Bromo-Picolin-Amide Butyrylamino Carboxamide Carboxamide Diacetamide Dicarboxamide Diethylacetamide Diethylacetamide Diethylaminoethyl-Carboxamide Diethylcarbamoyl Dihydroxypropyl-Isophthalamide Diisopropylcarbamoyl Dimethylacetamide Dimethylnicotinamide Dimethylnicotinamide Dipropylcarbamoyl Ethyl 2-(Amino)-2-Oxoacetate Formamide Formamidophenylboronic Acid Formamidophenylboronic Acid/Ester Formamidophenylboronic-Acid Isobutyramide Maleimide Maleimide Mercaptopropanamido Methoxybenzamide N,N-Dimethyl-Acetamide N,N-Dimethylamide N-Butyl-Carboxamide N-Ethyl-Carboxamide N-Ethylacetamide N-Hydroxy-Carboxamide N-Isopropyl-Carboxamide N-Methoxy-N-Methylamide N-Methyl-Carboxamide N-Methylacetamide Oxobutanamide Oxobutanamide Pentanamide Pentanamide Pivalamide Propanamide Propanamido Propanamido Propionamido Tert-Butylcarbamoy Thioamide

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzisoxazoles Benzofurans Benzothiazoles Benzothiophenes Benzoxazoles Cinnolines Dioxolanes Epoxides Furans Guanidines Imidazoles Imidazolidines Imidazolines Indazoles Indoles Indolines Isoquinolines Isothiazoles Isoxazoles Morpholines Naphthyridines Non-Halogenated Heterocycles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxadiazoles Oxazines Oxazoles Oxazolidines Oxazolines Oxetanes Phthalazines Piperazines Piperidines Purines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines Quinazolines Quinolines Quinoxalines Quinuclidines Spiroes Tetrahydrofurans Tetrahydroisoquinolines Tetrahydropyrans Tetrahydroquinolines Thiadiazoles Thiazines Thiazoles Thiazolidines Thiomorpholines Thiophenols Triazines Triazoles

By Functional Group+−

Acyl Chlorides Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amidines Amines Anhydrides Aryls Azoes Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Diazoes Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Hydrazones Hydroxylamines Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Sulfonyl Hydrazides Thioesters Thiols Thiophenes Thioureas Trifluoromethyls Ureas

Nitrogen related+−

RC(O)NR′R″

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