Home Chemistry Organic Building Blocks Iodides 2-Iodobenzamide
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —I,—C(O)NH2).
Sandmeyer Reaction: Iodobenzene can undergo a Sandmeyer reaction, where it is treated with a copper(I) salt and a source of nitrogen. This leads to the replacement of the iodine atom with a new functional group, such as an 【amine|https://www.ambeed.com/amines.html】, 【azide|https://www.ambeed.com/azides.html】, or 【cyanide|https://www.ambeed.com/nitriles.html】.
Hofmann Rearrangement: Benzamide can undergo Hofmann rearrangement when treated with chlorine or bromine in the presence of a strong base, resulting in the conversion of the amide group to an 【isocyanate|https://www.ambeed.com/isocyanates-and-isothiocyanates.html】 group. Further hydrolysis of the isocyanate can yield an amine with one fewer carbon atom.
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