Home Chemistry Heterocyclic Building Blocks Pyridines 3-Bromopyridine 1-Oxide
Substitution Reactions: Being a halogenated compound, 3-bromopyridine 1-oxide can undergo substitution reactions where the bromine atom is replaced by another nucleophile. This can include reactions such as nucleophilic substitution or metal-catalyzed reactions.
Oxidation-Reduction Reactions: The oxygen atom in the molecule can participate in oxidation-reduction reactions. Depending on the conditions, it may either be reduced to a hydroxyl group or oxidized to a different functional group.
Cyclization Reactions: The pyridine ring can participate in cyclization reactions, forming various cyclic compounds under suitable conditions. This can involve intramolecular reactions where the bromine or oxygen atom interacts with another part of the molecule to form a cyclic structure.
Cross-Coupling Reactions: 3-Bromopyridine 1-oxide can undergo cross-coupling reactions with suitable partners under appropriate conditions. For example, it can participate in Suzuki coupling, Stille coupling, Heck coupling, etc., leading to the formation of biaryl compounds or other coupled products.
Acid-Base Reactions: The nitrogen atom in the pyridine ring can undergo protonation or deprotonation reactions in the presence of suitable acids or bases, respectively.
Functional Group Transformations: Various functional group transformations are possible depending on the reagents and conditions used. For example, the bromine atom or the oxygen atom can undergo transformations to introduce different functional groups.
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5-Bromo-2-methyl-4-nitropyridine 1-oxide
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5-Bromo-4-methoxy-2-methylpyridine 1-oxide
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5-Bromo-2-(methoxycarbonyl)pyridine 1-oxide
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