Home Chemistry Organic Building Blocks Bromides 5-Bromo-1H-Pyrazolo[3,4-B]Pyridine
Nucleophilic Substitution: The bromine atom at the 5-position can undergo nucleophilic substitution reactions with nucleophiles (e.g., amines, thiols, etc.), leading to the replacement of the bromine atom with the nucleophile.
Metalation: The bromine atom can be replaced by a metal (e.g., lithium, magnesium) through metalation reactions, creating a reactive organometallic intermediate.
Suzuki Coupling: The bromine-substituted pyrazolo[3,4-b]pyridine can participate in Suzuki coupling reactions with boronic acids or boronate esters, leading to the formation of biaryl compounds.
Stille Coupling: Similar to Suzuki coupling, but using organostannanes.
Cyclization Reactions: The compound may participate in intramolecular cyclization reactions to form fused or spiro heterocyclic structures.
Reductive Dehalogenation: The bromine atom may be replaced with a hydrogen atom through reductive dehalogenation reactions.
Bromine Functionalization: The bromine atom may undergo oxidative transformations to introduce other functional groups.
Direct Arylation: The compound may undergo direct arylation reactions, introducing aryl groups at different positions of the pyrazolo[3,4-b]pyridine ring.
Halogenation of the Pyrazole Ring: The pyrazole ring may undergo halogenation reactions at various positions.
Deprotonation: Under appropriate conditions, the compound may undergo deprotonation to form an N-heterocyclic carbene, which can then participate in various catalytic reactions.
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5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde
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5-Bromo-3-methoxy-1H-pyrazolo[3,4-b]pyridine
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5-Bromo-6-methyl-1h-pyrazolo[3,4-b]pyridine
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5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine
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5-Bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine
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5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid
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3,5-Dibromo-1H-pyrazolo[3,4-b]pyridine
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