Home Chemistry Heterocyclic Building Blocks Pyridines 6-Chloronicotinic Acid
Acid-Base Reactions: Being a carboxylic acid, 6-chloronicotinic acid can undergo acid-base reactions with strong bases to form salts.
Esterification: The carboxylic acid group can undergo esterification with alcohols in the presence of acid catalysts to form esters.
Substitution Reactions: The chlorine atom can be substituted by various nucleophiles under appropriate conditions. For example, with primary amines, it can undergo nucleophilic substitution to form amides.
Reduction: The carboxylic acid group can be reduced to an alcohol under suitable reducing conditions, such as with lithium aluminum hydride (LiAlH4) or catalytic hydrogenation:
Halogenation: The chlorine atom can undergo further halogenation reactions under specific conditions, such as with halogenating agents like chlorine gas or N-chlorosuccinimide.
Aromatic Substitution: The aromatic ring can undergo various substitution reactions such as electrophilic aromatic substitution or nucleophilic aromatic substitution depending on the reagents and conditions.
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6-Chloro-5-(ethoxycarbonyl)nicotinic acid
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2-((tert-Butoxycarbonyl)amino)-6-chloronicotinic acid
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6-Chloro-2-(difluoromethoxy)nicotinic acid
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