Home Chemistry Heterocyclic Building Blocks Pyridines 6-Chloropicolinic Acid
Substitution Reactions: The chlorine atom can be substituted with other functional groups via nucleophilic substitution reactions. For instance, substitution with amino groups, alkoxides, or thiolates can occur under appropriate conditions.
Acid-Base Reactions: Like other carboxylic acids, 6-chloropicolinic acid can undergo acid-base reactions. It can donate a proton from the carboxylic acid group, resulting in the formation of its conjugate base.
Oxidation Reactions: The pyridine ring can be oxidized to give various oxidation products. For example, oxidation with strong oxidizing agents like chromic acid can lead to the formation of corresponding carboxylic acids or ketones.
Reduction Reactions: Reduction of the pyridine ring can occur, yielding dihydro derivatives. For example, reduction with metal hydrides such as lithium aluminum hydride (LiAlH4) can lead to the formation of piperidine derivatives.
Metal Complexation: The pyridine nitrogen can coordinate with transition metal ions to form metal complexes. This can be utilized in various catalytic or coordination chemistry applications.
Esterification/Amidation: The carboxylic acid group can undergo esterification or amidation reactions with alcohols or amines, respectively, yielding corresponding esters or amides.
Condensation Reactions: 6-Chloropicolinic acid can participate in condensation reactions, such as the formation of heterocyclic compounds by reacting with appropriate reagents.
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6-Chloro-5-methylpyridine-2-carboxylic acid
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6-Chloro-5-(trifluoromethyl)picolinic acid
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6-Chloro-5-(2,2,2-trifluoroethoxy)picolinic acid
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3-Amino-6-chloropyridine-2-carboxylic acid
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5-Bromo-6-chloropyridine-2-carboxylic acid
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6-Chloro-3-(trifluoromethyl)pyridine-2-carboxylic acid
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