Inhibitors/Agonists Endocrinology/Hormones ACE

ACE

Angiotensin-converting enzyme (ACE) primarily exists in two isoforms, ACE and ACE2, serving as zinc metallopeptidases expressed in tissues such as the cardiovascular system and kidneys. ACE is responsible for converting angiotensin I into the more active angiotensin II, regulating blood pressure and fluid balance. On the other hand, ACE2 catalyzes the generation of angiotensin 1-7 from angiotensin II, providing a balancing effect on ACE activity. This process is a crucial link in the Renin-Angiotensin-Aldosterone System (RAAS), influencing the function of the cardiovascular system. Variations in the ACE gene are associated with an increased risk of cardiovascular diseases such as hypertension and heart failure, while ACE2 is implicated in the mechanism of coronaviruses invading human cells, highlighting its crucial role in diseases.