Chemistry
Organic Building Blocks
Bromides
(2-bromophenyl)methanamine
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Br,—CH2NH2).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Mannich Reaction: Phenylmethanamine can undergo Mannich reactions, where it reacts with formaldehyde and a secondary 【amine|https://www.ambeed.com/amines.html】 to form β-amino carbonyl compounds.
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(2-Bromo-4-fluorophenyl)methanamine hydrochloride
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(2-Bromo-5-methoxyphenyl)methanamine hydrochloride
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(2-Bromo-4-(trifluoromethyl)phenyl)methanamine
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(2-Bromo-4-chlorophenyl)methanamine hydrochloride