Chemistry Heterocyclic Building Blocks Pyridines (3-fluoropyridin-2-yl)methanamine
Ambeed provide 5 derivatives of (3-fluoropyridin-2-yl)methanamine.
These compounds have the same murcko framework: (3-fluoropyridin-2-yl)methanamineNucleophilic substitution: The amino group (-NH2) can act as a nucleophile in substitution reactions, replacing other functional groups or atoms attached to the pyridine ring or the methylene group.
Acylation: The amino group can react with acylating agents to form amides.
Alkylation: The amino group can undergo alkylation reactions, where an alkyl group is introduced to the nitrogen atom.
Reductive amination: The amine group can react with carbonyl compounds in the presence of reducing agents to form secondary or tertiary amines.
Heterocyclization: The amino group can participate in ring-closure reactions to form heterocyclic compounds, especially with electrophilic groups on the pyridine ring.
Oxidation: Both the amino and the pyridine ring can undergo oxidation reactions under suitable conditions.
Protonation: The amine group can undergo protonation reactions under acidic conditions.
Metal complexation: The compound can coordinate with metal ions, leading to the formation of metal complexes.
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(3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)methanamine
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(3-Fluoropyridin-2-yl)methanamine dihydrochloride
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2-Aminomethyl-3-fluoropyridine hydrochloride
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(3,5-difluoropyridin-2-yl)methanamine dihydrochloride