Chemistry Heterocyclic Building Blocks Pyridines (6-methylpyridin-2-yl)methanamine
Ambeed provide 6 derivatives of (6-methylpyridin-2-yl)methanamine.
These compounds have the same murcko framework: (6-methylpyridin-2-yl)methanamineNucleophilic Substitution: The amine group can undergo nucleophilic substitution reactions with electrophiles, replacing a substituent on the amine nitrogen with another group.
Alkylation/Acylation: The amine nitrogen can be alkylated or acylated, leading to the formation of secondary or tertiary amines, or amides, respectively.
Ring Substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions, such as halogenation, nitration, sulfonation, or Friedel-Crafts reactions.
Reduction: The imine group (C=N) can be reduced to form secondary amines, typically using reducing agents like hydrogen gas over a metal catalyst or sodium borohydride.
Condensation Reactions: The amine group can undergo condensation reactions with carbonyl compounds to form imines or enamines.
Protonation: The amine nitrogen can accept a proton, becoming a positively charged ammonium ion.
Hofmann Elimination: Under certain conditions, the amine group can undergo Hofmann elimination to produce an alkene and amine oxide.
Oxidation: The amine can be oxidized to form either an imine or an amine oxide.
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(5,6-Dimethylpyridin-2-yl)methanamine dihydrochloride
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(5,6-Dimethylpyridin-2-yl)methanamine hydrochloride
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(3-Fluoro-6-methylpyridin-2-yl)methanamine hydrochloride
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(6-Methylpyridin-2-yl)methanamine hydrochloride
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(4-Bromo-6-methylpyridin-2-yl)methanamine