Chemistry Heterocyclic Building Blocks Pyrrolidines (9H-fluoren-9-yl)methyl pyrrolidine-1-carboxylate
Ambeed provide 26 derivatives of (9H-fluoren-9-yl)methyl pyrrolidine-1-carboxylate.
These compounds have the same murcko framework: (9H-fluoren-9-yl)methyl pyrrolidine-1-carboxylate.
Hydrolysis: Under acidic or basic conditions, the ester linkage in the compound can undergo hydrolysis to yield the corresponding carboxylic acid and alcohol.
Reduction: The carbonyl group in the ester can be reduced to the corresponding alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Amine Reactions: The pyrrolidine ring contains a secondary amine group, which can react with various electrophiles. For example, it can undergo acylation reactions with acid chlorides or anhydrides to form amides. It can also react with alkyl halides to form N-substituted pyrrolidines.
Grignard Reactions: The compound can react with Grignard reagents to form tertiary alcohols or other derivatives.
Cross-Coupling Reactions: If there are suitable functional groups on the benzyl or fluorenyl moieties, they can undergo cross-coupling reactions such as Suzuki-Miyaura or Heck reactions.
Amide Hydrolysis: The amide bond in the compound can undergo hydrolysis under acidic or basic conditions to form the corresponding carboxylic acid and amine.
Oxidation: The benzyl group can be oxidized to the corresponding benzoic acid under appropriate conditions.
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(R)-2-(1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidin-2-yl)acetic acid
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(2S,4S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
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(R)-2-((1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidin-2-yl)methoxy)acetic acid
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(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-3-carboxylic acid
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(2R,4S)-4-Alloc-amino-1-Fmoc-Pyrrolidine-2-carboxylic acid
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(2R,4R)-4-Alloc-amino-1-Fmoc-pyrrolidine-2-carboxylic acid
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(9H-Fluoren-9-yl)methyl 3-hydroxypyrrolidine-1-carboxylate