Chemistry Organic Building Blocks Aryls (benzylsulfonyl)benzene
Nucleophilic Substitution Reactions: The sulfone group can undergo nucleophilic substitution reactions, where a nucleophile (such as a strong base or an organometallic compound) attacks the sulfur atom, leading to the displacement of the leaving group (usually a phenyl group).
Electrophilic Aromatic Substitution: The benzene ring can undergo electrophilic aromatic substitution reactions, similar to other benzene derivatives. Common electrophilic aromatic substitution reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions. These reactions can be used to introduce various substituents onto the benzene ring.
Reduction: The sulfone group can be reduced to a sulfide group using reducing agents like sodium borohydride (NaBH4). This reaction can be used to convert the sulfonyl group into a simpler group.
Oxidation: The sulfone group can be oxidized to a sulfonate or sulfoxide group using strong oxidizing agents. For example, m-chloroperoxybenzoic acid (m-CPBA) can be used to convert the sulfone into a sulfonate.
Cross-Coupling Reactions: (Benzylsulfonyl)benzene can be used as a substrate in cross-coupling reactions, such as Suzuki, Heck, or Sonogashira reactions, to form C-C or C-heteroatom bonds between the aromatic ring and other organic compounds.
Dehydrogenation: The benzene ring can undergo dehydrogenation reactions to form a benzyne intermediate, which can react with various nucleophiles or undergo further chemical transformations.
Hydrogenation: The benzene ring can be hydrogenated using catalysts like palladium or platinum, leading to the reduction of the aromatic ring.
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2-((Phenylsulfonyl)methyl)benzaldehyde
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1,2-Difluoro-4-(isocyano(tosyl)methyl)benzene
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(2,4-DImethylphenyl)(isocyano)methyl 4-methylphenyl sulfone
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1-Chloro-3-(isocyano(tosyl)methyl)benzene
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1-((Isocyano(p-tolyl)methyl)sulfonyl)-4-methylbenzene