Chemistry Heterocyclic Building Blocks Pyrrolidines (R)-3-(pyrrolidin-2-yl)pyridine

(R)-3-(pyrrolidin-2-yl)pyridine

Ambeed provide 9 derivatives of (R)-3-(pyrrolidin-2-yl)pyridine.

These compounds have the same murcko framework: (R)-3-(pyrrolidin-2-yl)pyridine.

Nucleophilic Substitution: The pyrrolidine nitrogen can act as a nucleophile, attacking electrophilic centers in other molecules. For example, it can react with alkyl halides to form N-alkylated pyrrolidines.
Acid-Base Reactions: The pyrrolidine nitrogen can act as a base, accepting a proton (H+) from an acidic compound.
Formation of Complexes: (R)-3-(pyrrolidin-2-yl)pyridine can coordinate with transition metals to form complexes. This can be useful in catalytic reactions.
Redox Reactions: Depending on the reaction conditions, it can undergo oxidation or reduction reactions, particularly if there are suitable reagents or catalysts present.
Esterification or Amidation: The pyridine ring can potentially participate in esterification or amidation reactions, where it reacts with carboxylic acids or acid chlorides to form esters or amides, respectively.
Alkylation or Acylation: The pyridine ring can also undergo alkylation or acylation reactions, where it reacts with alkyl halides or acyl chlorides to introduce substituents onto the ring.
Ring-Opening Reactions: Depending on the reaction conditions and reagents, the pyrrolidine ring might undergo ring-opening reactions, forming different compounds.

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(3aR,6aS)-octahydrocyclopenta[c]pyrrole (9H-fluoren-9-yl)methyl pyrrolidine-1-carboxylate (R)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid (R)-2-benzhydrylpyrrolidine (R)-3-(pyrrolidin-2-yl)pyridine (R)-3-benzylpyrrolidine (R)-3-phenylpyrrolidine (S)-2-benzhydrylpyrrolidine (S)-3-phenylpyrrolidine (S)-N-(((S)-tetrahydro-2H-pyran-2-yl)methyl)pyrrolidine-2-carboxamide (S)-N-(4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (S)-N-phenethyl-3-(pyrrolidin-2-yl)propanamide 1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid 1-(3-chlorophenyl)pyrrolidine 1-(phenylsulfonyl)pyrrolidine 1-(pyrrolidin-1-yl)ethan-1-one 1-benzyl 2-methyl pyrrolidine-1,2-dicarboxylate 1-benzylpyrrolidin-2-one 1-benzylpyrrolidine 1-methylpyrrolidin-2-one 1-phenylpyrrolidin-2-one 2,2-dimethylpyrrolidine 2,5-dioxopyrrolidin-1-yl ((benzyloxy)carbonyl)glycinate 2,5-dioxopyrrolidin-1-yl benzoate 2,8-diazaspiro[4.5]decan-3-one 2-((3-phenylpropyl)amino)-1-(pyrrolidin-1-yl)ethan-1-one 2-(2-chlorophenyl)pyrrolidine 2-(2-fluorophenyl)pyrrolidine 2-(3-fluorophenyl)pyrrolidine 2-(methoxymethyl)pyrrolidine 2-(pyrrolidin-1-yl)benzoic acid 2-(pyrrolidin-1-yl)pyridine 2-(pyrrolidin-1-yl)pyrimidine 2-(pyrrolidin-2-yl)acetic acid 2-(pyrrolidin-2-yl)pyridine 2-(pyrrolidin-3-yl)acetic acid 2-amino-1-(pyrrolidin-1-yl)ethan-1-one 2-azabicyclo[2.2.1]heptane 2-methyl-1-phenyl-1H-pyrrole 2-methylpyrrolidine 3,3-difluoropyrrolidine 3-(pyrrolidin-2-yl)pyridine 3-aminopyrrolidin-2-one 3-bromopyrrolidine 3-hydroxypyrrolidin-2-one 3-phenoxypyrrolidine 3-phenyl-1-(pyrrolidin-1-yl)propan-1-one 3-phenylpyrrolidine 4-(hydroxymethyl)pyrrolidin-2-one 4-(pyrrolidin-1-yl)aniline 4-(pyrrolidin-1-yl)piperidine 4-hydroxypyrrolidin-2-one 4-phenylpyrrolidin-2-one 4H-thieno[3,4-c]pyrrole-4,6(5H)-dione 5-(aminomethyl)pyrrolidin-2-one 5-(hydroxymethyl)pyrrolidin-2-one 5-azaspiro[2.4]heptane 5-oxopyrrolidine-2-carboxylic acid 6-azaspiro[3.4]octane benzyl (R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate benzyl (R)-3-aminopyrrolidine-1-carboxylate benzyl (S)-pyrrolidin-3-ylcarbamate benzyl 3-hydroxypyrrolidine-1-carboxylate benzyl-2-(hydroxymethyl)pyrrolidine-1-carboxylate benzyl-3-aminopyrrolidine-1-carboxylate ethyl 5-oxopyrrolidine-2-carboxylate hexahydro-1H-pyrrolizine methyl 5-oxopyrrolidine-2-carboxylate methyl prolinate methyl pyrrolidine-3-carboxylate N,N-dimethylpyrrolidin-3-amine N-methylpyrrolidin-3-amine octahydrocyclopenta[c]pyrrole phenyl(pyrrolidin-1-yl)methanone proline pyrrolidin-2-ylmethanamine pyrrolidin-2-ylmethanol pyrrolidin-3-ol pyrrolidin-3-ylmethanamine pyrrolidin-3-ylmethanol pyrrolidine-2-carbonitrile pyrrolidine-2-carboxamide pyrrolidine-3-carbonitrile pyrrolidine-3-carboxylic acid tert-butyl (2-oxopyrrolidin-3-yl)carbamate tert-butyl (5-oxopyrrolidin-3-yl)carbamate tert-butyl 2-oxopyrrolidine-1-carboxylate tert-butyl 3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate tert-butyl 3-hydroxypyrrolidine-1-carboxylate tert-butyl 3-methoxypyrrolidine-1-carboxylate tert-butyl pyrrolidin-3-ylcarbamate tert-butyl pyrrolidine-1-carboxylate

By Key Group+−

(R)-1-amino-2-(methoxymethyl)pyrrolidine (S)-1-amino-2-(methoxymethyl)pyrrolidine 1-(prop-1-en-2-yl)pyrrolidine acetylpyrrolidine aminopyrrolidine benzhydrylpyrrolidine benzylpyrrolidine bipyrrolidine bromopyrrolidine carbamoylpyrrolidine cyanopyrrolidine difluoropyrrolidine dihydroxypyrrolidine dimethylpyrrolidine dioxaborolane-pyrrolidine dioxopyrrolidin ethylpyrrolidine fluoropyrrolidine formylpyrrolidine hydroxypyrrolidine mercaptopyrrolidine methoxypyrrolidine methyl 2-pyrrolidone-5(S)-carboxylate methylenepyrrolidine methylpyrrolidine N-bromosuccinimide N-chlorosuccinimide N-hydroxysuccinimide N-iodosuccinimide N-methyl-2-pyrrolidinone N-phenylmaleimide other-pyrrolidine phenoxypyrrolidine phenylpyrrolidine pyridine-pyrrolidine pyrrolidine-benzene-boronic acid/ester pyrrolidine-carboxylate pyrrolidine-carboxylic acid pyrrolidine-hydrochloride pyrrolidine-methanol pyrrolidine-pyrimidine pyrrolidinone trifluoromethyl-phenyl-pyrrolidine

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Azetidines Epoxides Guanidines Imidazoles Indazoles Indoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxadiazoles Oxetanes Piperidines Pyrazines Pyrazoles Pyridines Pyrimidines Pyrrolines Quinolines Spiroes Tetrahydropyrans Thiazoles

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Alcohols Aldehydes Alkenyls Alkynyls Amides Amines Aryls Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Iodides Ketones Nitriles Nitroes Organoboron Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Thiols Trifluoromethyls Ureas

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