Chemistry
Heterocyclic Building Blocks
Morpholines
(R)-3-phenylmorpholine
Amidation: (R)-3-phenylmorpholine can be amidated with acyl chlorides or anhydrides to form amide derivatives. This reaction can be important in the synthesis of various amide-containing compounds.
Ring Opening Reactions: The morpholine ring can be opened under acidic or basic conditions, leading to the formation of open-chain compounds. This can be a crucial step in the synthesis of various derivatives.
Reductive Amination: (R)-3-phenylmorpholine can be used as a substrate in reductive amination reactions, where it can react with aldehydes or ketones in the presence of reducing agents to form secondary amines.
Alkylation: The nitrogen atom in (R)-3-phenylmorpholine can be alkylated using alkyl halides or alkyl sulfonates to introduce alkyl groups.
Acylation: (R)-3-phenylmorpholine can undergo acylation reactions to form ester derivatives. This reaction typically involves the reaction of the compound with acyl chlorides or anhydrides.
Redox Reactions: Depending on the reaction conditions, (R)-3-phenylmorpholine may undergo redox reactions when exposed to oxidizing or reducing agents.
Metal-Catalyzed Reactions: Various metal catalysts can be used to facilitate reactions involving (R)-3-phenylmorpholine, such as cross-coupling reactions or C-H functionalization.
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Methyl (R)-2-(morpholin-3-yl)benzoate hydrochloride
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(R)-3-(2-Bromophenyl)morpholine hydrochloride
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(R)-3-(2-Methoxyphenyl)morpholine hydrochloride