Chemistry Heterocyclic Building Blocks Oxazolines (R)-4-benzyl-2-(pyridin-2-yl)-4,5-dihydrooxazole

(R)-4-benzyl-2-(pyridin-2-yl)-4,5-dihydrooxazole

Ambeed provide 7 derivatives of (R)-4-benzyl-2-(pyridin-2-yl)-4,5-dihydrooxazole.

These compounds have the same murcko framework: (R)-4-benzyl-2-(pyridin-2-yl)-4,5-dihydrooxazole.

Substitution Reactions: Depending on the reagents and conditions, the pyridin-2-yl group or the benzyl group can undergo substitution reactions, where another group replaces one of these groups.
Oxidation/Reduction Reactions: The oxazole ring can be subject to oxidation or reduction, leading to changes in the oxidation state of the compound.
Ring-Opening Reactions: Oxazoles can be opened under acidic or basic conditions, yielding products with an open chain structure.
Cross-Coupling Reactions: The benzyl group can participate in cross-coupling reactions with other organic compounds, such as Suzuki, Heck, or Sonogashira reactions, to form new C-C bonds.
Acylation/Alkylation Reactions: Functional groups like the pyridine ring or the oxazole can be subjected to acylation or alkylation reactions to introduce new substituents.
Cyclization Reactions: Depending on the conditions, the compound may undergo intramolecular cyclization reactions, forming new rings or functional groups.
Hydrogenation Reactions: The compound can be hydrogenated to saturate some or all of the double bonds in the molecule.

Further Reading:
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Conditions to empty

Framework+−

(3aR,8aS)-2-(pyridin-2-yl)-3a,8a-dihydro-8H-indeno[1,2-d]oxazole (3aS,8aR)-2-(pyridin-2-yl)-3a,8a-dihydro-8H-indeno[1,2-d]oxazole (4R,5S)-4,5-diphenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (R)-4-benzyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (R)-4-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (S)-4-(tert-butyl)-2-(pyridin-2-yl)-4,5-dihydrooxazole (S)-4-benzyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (S)-4-isopropyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (S)-4-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole 1,3-bis(4,5-dihydrooxazol-2-yl)benzene 2,2'-(1,3-diphenylpropane-2,2-diyl)bis(4,5-dihydrooxazole) 2,2'-(2-phenylethane-1,1-diyl)bis(4,5-dihydrooxazole) 2,3-dihydropyrazolo[5,1-b]oxazole 2,6-bis(4,5-dihydrooxazol-2-yl)pyridine 2-(6-benzhydrylpyridin-2-yl)-4,5-dihydrooxazole 2-(6-cyclopropylpyridin-2-yl)-4,5-dihydrooxazole 2-(benzo[b]thiophen-2-yl)-4,5-dihydrooxazole 2-(pyridin-2-ylmethyl)-4,5-dihydrooxazole 2-(quinolin-2-yl)-4,5-dihydrooxazole 2-phenyl-4,5-dihydrooxazole 4,4',5,5'-tetrahydro-2,2'-bioxazole 4-(tert-butyl)-2-(pyridin-2-yl)-4,5-dihydrooxazole 4-isopropyl-2-(pyridin-2-yl)-4,5-dihydrooxazole bis((3aR,8aS)-3a,8a-dihydro-8H-indeno[1,2-d]oxazol-2-yl)methane bis((3aS,8aR)-3a,8a-dihydro-8H-indeno[1,2-d]oxazol-2-yl)methane bis(4,5-dihydrooxazol-2-yl)methane

By Key Group+−

dihydrooxazole

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Piperidines Pyridines Spiroes

By Functional Group+−

Alkenyls Amides Aryls Chiral Building Blocks Esters Nitroes Sulfonates

By Chemical Elements+−

    Bx
    Cx
    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

    Druglikeness+−

    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    By Configuration+−

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