Chemistry Heterocyclic Building Blocks Pyridines 1,2,3,6-tetrahydropyridine
Basicity and Nucleophilicity: Piperidine is a basic compound due to the lone pair of electrons on its nitrogen atom. It can act as a nucleophile in reactions with electrophiles, such as alkyl halides.
Alkylation: Piperidine can undergo alkylation reactions with alkyl halides to form N-alkyl piperidines. For example, when reacted with an alkyl halide like methyl iodide, it can yield N-methylpiperidine.
Reductive Amination: Piperidine can participate in reductive amination reactions where it reacts with aldehydes or ketones in the presence of reducing agents like sodium cyanoborohydride or sodium borohydride to form secondary or tertiary amines.
Ring-Opening Reactions: Depending on the conditions, piperidine can undergo ring-opening reactions, particularly under acidic conditions, leading to the formation of open-chain compounds.
Oxidation: Piperidine can be oxidized under certain conditions to form piperidone or other oxidized products.
Cyclization: Piperidine can also be used as a starting material in the synthesis of other heterocyclic compounds by further functionalization or cyclization reactions.
Redox Reactions: Piperidine can participate in various redox reactions depending on the specific reaction conditions and reagents used.
Reductive Cleavage: In certain reactions, piperidine can undergo reductive cleavage to break the ring and form simpler products.
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tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate
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tert-Butyl 4-(((trifluoromethyl)sulfonyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate
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tert-Butyl 4-methyl-5,6-dihydropyridine-1(2H)-carboxylate
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1-tert-Butyl 4-methyl 5,6-dihydropyridine-1,4(2H)-dicarboxylate
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tert-Butyl 4-(trifluoromethyl)-5,6-dihydropyridine-1(2H)-carboxylate
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tert-Butyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)-5,6-dihydropyridine-1(2H)-carboxylate
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tert-Butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate
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tert-Butyl 4-bromo-5,6-dihydropyridine-1(2H)-carboxylate
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tert-Butyl 5-hydroxy-5,6-dihydropyridine-1(2H)-carboxylate
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tert-Butyl 3-bromo-5,6-dihydropyridine-1(2H)-carboxylate
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Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate hydrochloride
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Methyl 1-methyl-1,2,3,6-tetrahydropyridine-4-carboxylate
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(1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)boronic acid
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2-Methyl-2-(1,2,3,6-tetrahydropyridin-4-yl)propan-1-ol
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1-Boc-1,2,3,6-tetrahydropyridine-4-carboxylic Acid
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Prop-2-yn-1-yl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide
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1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid