Chemistry
Organic Building Blocks
Chlorides
1,2-dichloro-4-fluorobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Cl,—F).
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
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