Chemistry Heterocyclic Building Blocks Pyridines 1,3-dihydro-2H-pyrrolo[2,3-c]pyridin-2-one
Ambeed provide 5 derivatives of 1,3-dihydro-2H-pyrrolo[2,3-c]pyridin-2-one.
These compounds have the same murcko framework: 1,3-dihydro-2H-pyrrolo[2,3-c]pyridin-2-one.
Substitution Reactions: The compound can undergo nucleophilic substitution reactions, where a nucleophile replaces a leaving group. For instance, if a strong nucleophile is introduced, it may replace one of the substituents on the molecule.
Acylation: It can undergo acylation reactions where an acyl group (-COR) is introduced into the molecule. For example, treatment with an acyl chloride or anhydride can lead to the formation of an acylated product.
Reduction: The compound may be reduced to its corresponding dihydropyridin-2-one derivative, typically using reducing agents like sodium borohydride or catalytic hydrogenation.
Ring-Closure Reactions: Depending on the reaction conditions, it may undergo ring-closure reactions to form products with different ring sizes.
Functional Group Interconversions: Various functional group interconversions are possible, including oxidation or reduction of functional groups, introduction of new functional groups, or modification of existing ones.
Condensation Reactions: It may participate in condensation reactions with suitable reagents to form larger structures.
Cyclization Reactions: Intramolecular cyclization reactions may occur under certain conditions, forming cyclic compounds.
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tert-Butyl 2-oxo-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate
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7-Chloro-1H-pyrrolo[2,3-c]pyridin-2(3H)-one
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5-Chloro-1H-pyrrolo[2,3-c]pyridin-2(3H)-one
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5-Bromo-1H-pyrrolo[2,3-c]pyridin-2(3H)-one
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4-Bromo-1H-pyrrolo[2,3-c]pyridin-2(3H)-one