Chemistry Heterocyclic Building Blocks Pyridines 1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one
Ambeed provide 11 derivatives of 1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one.
These compounds have the same murcko framework: 1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one.
Alkylation or Arylation: The nitrogen atom can be alkylated or arylated with alkyl or aryl halides in the presence of a suitable base.
Reduction: You can reduce the carbonyl group (C=O) to form a corresponding alcohol (C-OH) using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Oxidation: The alcohol group can be oxidized to the corresponding ketone (C=O) or carboxylic acid (COOH) using appropriate oxidizing agents.
Ring Closure Reactions: Depending on the conditions, ring-closing reactions can occur to form various cyclic compounds.
Condensation Reactions: It can participate in condensation reactions to form other heterocyclic compounds.
Substitution Reactions: The pyridine ring can undergo electrophilic or nucleophilic substitutions depending on the reagents and conditions.
Base-Catalyzed Reactions: The compound can undergo various base-catalyzed reactions, such as the Claisen condensation or Michael addition, depending on the reagents and functional groups present.
Heterocycle Formation: It can participate in reactions that lead to the formation of other heterocyclic compounds, such as the synthesis of fused ring systems.
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5,6-Dichloro-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
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7-Bromo-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
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6-Bromo-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-2-one
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Methyl 2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-3-carboxylate
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6-Bromo-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
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6-Methyl-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
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Methyl 2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-5-carboxylate
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2-Oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile
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7-Methyl-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
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7-Chloro-1H-pyrrolo[3,2-b]pyridin-2(3H)-one