Chemistry Heterocyclic Building Blocks Pyridines 1,4-di(pyridin-4-yl)benzene
Ambeed provide 5 derivatives of 1,4-di(pyridin-4-yl)benzene.
These compounds have the same murcko framework: 1,4-di(pyridin-4-yl)benzene.
Electrophilic Aromatic Substitution: The benzene ring can undergo electrophilic aromatic substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation or alkylation.
Cross-Coupling Reactions: 1,4-di(pyridin-4-yl)benzene can be used in various cross-coupling reactions, such as Suzuki-Miyaura, Heck, or Stille coupling reactions to introduce new functional groups on the benzene ring.
Reduction: Reduction reactions can be carried out to convert the pyridine rings to piperidine rings. For example, catalytic hydrogenation can be used to reduce the pyridine rings to piperidines.
Oxidation: The compound can be oxidized to introduce oxygen-containing functional groups, such as ketones or aldehydes, on the benzene ring.
Alkylation and Acylation: The pyridine nitrogen atoms can be alkylated or acylated to introduce various substituents.
Nucleophilic Aromatic Substitution: Depending on the reaction conditions, nucleophilic aromatic substitution reactions may occur on the pyridine rings.
Functional Group Transformation: Various functional group transformations, including reactions like halogenation, sulfonation, or nitration, can be performed to modify the compound.
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4,4'-(2,5-Dimethoxy-1,4-phenylene)dipyridine
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4,4'-(2,5-Difluoro-1,4-phenylene)dipyridine
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4,4'-(1,4-Phenylene)bis(pyridine-2,6-dicarboxylic acid)