Chemistry
Organic Building Blocks
Fluorinated Building Blocks
1,4-difluorobenzene
These compounds have the same murcko framework: benzene,and at least 1 kind of functional groups( —F).
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
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1,4-Difluoro-2-(prop-2-yn-1-yloxy)benzene
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tert-Butyl 2-(2,5-difluorobenzoyl)hydrazinecarboxylate