1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine-Piperazines| Ambeed

Chemistry Heterocyclic Building Blocks Piperazines 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine

1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine

Ambeed provide 6 derivatives of 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine.

These compounds have the same murcko framework: 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine.

Borylation Reactions: The boron atom in the dioxaborolane group can undergo various borylation reactions, such as Suzuki-Miyaura cross-coupling reactions, which can be used to introduce different substituents onto the pyridine ring.
Halogenation: The pyridine ring can undergo halogenation reactions, such as bromination or chlorination, to introduce halogen substituents.
Nucleophilic Substitution: The piperazine nitrogen atoms can act as nucleophiles and undergo substitution reactions with various electrophiles. For example, they can react with alkyl halides to form alkylated derivatives.
Arylation: The pyridine ring can undergo C-H arylation reactions, where aryl groups are introduced at specific positions on the pyridine ring.
Reduction: The compound can be reduced to convert the boron-containing group into a boronate ester or alcohol.
Functional Group Interconversion: Various functional groups, such as amides, esters, or ketones, can be introduced or modified on the piperazine or pyridine moieties through standard organic reactions.
Condensation Reactions: The compound may participate in condensation reactions with other compounds containing suitable functional groups, leading to the formation of heterocyclic or complex molecules.