Chemistry Heterocyclic Building Blocks Pyridines 1-(pyridin-2-yl)ethan-1-amine
Ambeed provide 15 derivatives of 1-(pyridin-2-yl)ethan-1-amine.
These compounds have the same murcko framework: 1-(pyridin-2-yl)ethan-1-amineAcylation: The amine group can undergo acylation reactions with acid chlorides, acid anhydrides, or carboxylic acids to form amides.
Alkylation/Acylation of the pyridine Ring: The pyridine ring can undergo Friedel-Crafts alkylation or acylation reactions, although the nitrogen atom in the ring deactivates it toward electrophilic aromatic substitution reactions.
Reductive Amination: The amine group can undergo reductive amination with carbonyl compounds (aldehydes or ketones) to form secondary amines.
Substitution Reactions: The amine group can undergo substitution reactions such as nucleophilic substitution or elimination reactions under appropriate conditions.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds to form imines or Schiff bases.
Oxidation: The amine group can be oxidized to form amine oxides or further oxidized to nitro compounds under strong oxidizing conditions.
Protonation: The amine group can be protonated under acidic conditions, influencing its reactivity in subsequent reactions.
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1-(3-Fluoropyridin-2-yl)ethan-1-amine dihydrochloride
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(R)-2-(1-Aminoethyl)nicotinonitrile dihydrochloride
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(R)-1-(3-Methylpyridin-2-yl)ethanamine dihydrochloride
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(R)-1-(3-Methylpyridin-2-yl)ethanamine
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1-(5-Methylpyridin-2-yl)ethanamine dihydrochloride
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1-(3-Chloro-5-fluoropyridin-2-yl)ethanamine
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1-(3-Bromopyridin-2-yl)ethan-1-amine dihydrochloride
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1-(3-Bromo-5-chloropyridin-2-yl)ethanamine hydrochloride
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1-(4-Methoxypyridin-2-yl)ethan-1-amine
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(R)-1-(Pyridin-2-yl)ethanamine dihydrochloride
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(R)-1-(4-(Trifluoromethyl)pyridin-2-yl)ethanamine hydrochloride
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(R)-1-(3-Fluoropyridin-2-yl)ethanamine dihydrochloride