Chemistry Heterocyclic Building Blocks Pyridines 1-(pyridin-2-yl)ethan-1-one
Ambeed provide 36 derivatives of 1-(pyridin-2-yl)ethan-1-one.
These compounds have the same murcko framework: 1-(pyridin-2-yl)ethan-1-oneNucleophilic Addition Reactions: The carbonyl group of α-picolinaldehyde is susceptible to nucleophilic attack. Reactions such as Grignard reactions, cyanohydrin formation, and addition of amines or hydrazines can occur at the carbonyl carbon.
Condensation Reactions: α-Picolinaldehyde can undergo condensation reactions with various nucleophiles to form imines or iminium ions. These reactions can be catalyzed by acids or bases.
Oxidation Reactions: The aldehyde group of α-picolinaldehyde can be oxidized to a carboxylic acid or other oxidized derivatives using oxidizing agents like potassium permanganate, chromic acid, or Tollens' reagent.
Reduction Reactions: The carbonyl group can be reduced to the corresponding alcohol using reducing agents such as sodium borohydride or lithium aluminum hydride.
Substitution Reactions: The pyridine ring can undergo substitution reactions, such as electrophilic aromatic substitution or nucleophilic aromatic substitution, depending on the conditions and reagents used.
Cyclization Reactions: Depending on the reaction conditions and the presence of suitable functional groups, α-picolinaldehyde can undergo cyclization reactions to form heterocyclic compounds.
Cross-Coupling Reactions: α-Picolinaldehyde can participate in cross-coupling reactions with various coupling partners, such as organometallic reagents (e.g., organozinc or organoboron compounds) or transition metal catalysts.
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1-(4-(Dimethylamino)pyridin-2-yl)ethanone
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1-(5-Methyl-3-nitropyridin-2-yl)ethanone
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1-(4-Chloro-3-fluoropyridin-2-yl)ethanone
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1-(3-Bromo-6-fluoropyridin-2-yl)ethanone
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1-(4-(Trifluoromethyl)pyridin-2-yl)ethanone
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1-(3-Bromo-6-(trifluoromethyl)pyridin-2-yl)ethanone