Chemistry Heterocyclic Building Blocks Pyridines 1-(pyridin-2-yl-l2-azaneyl)ethan-1-one
Ambeed provide 12 derivatives of 1-(pyridin-2-yl-l2-azaneyl)ethan-1-one.
These compounds have the same murcko framework: 1-(pyridin-2-yl-l2-azaneyl)ethan-1-oneNucleophilic Addition: As a ketone, it can undergo nucleophilic addition reactions. For instance, reaction with a strong nucleophile like a Grignard reagent or an organolithium compound could yield a substituted alcohol after hydrolysis.
Aldol Condensation: Under basic conditions, 2-pyridyl ketone can undergo aldol condensation with itself or other carbonyl compounds to form β-hydroxy ketones or β-diketones.
Substitution Reactions: The pyridine ring can undergo substitution reactions. For example, it could react with electrophiles like acyl chlorides or acid acid anhydrides to form substituted pyridines.
Vilsmeier-Haack Reaction: It can react with a mixture of phosphoryl chloride and DMF (N,N-Dimethylformamide) to yield a substituted pyridine ring.
Friedel-Crafts Acylation: The pyridine ring can undergo acylation reactions under Friedel-Crafts conditions, typically with acid chlorides or acid anhydrides in the presence of Lewis acids.
Reduction: It can be reduced to the corresponding alcohol using reducing agents like sodium borohydride or lithium aluminum hydride.
Oxidation: Under suitable conditions, it can be oxidized to the corresponding carboxylic acid using oxidizing agents like potassium permanganate or chromic acid.
Heterocyclic Chemistry: It can participate in various heterocyclic chemistry reactions typical of pyridines, such as cyclization reactions to form fused heterocycles.
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