Chemistry Heterocyclic Building Blocks Pyridines 1-(pyridin-3-yl)piperazine
Ambeed provide 13 derivatives of 1-(pyridin-3-yl)piperazine.
These compounds have the same murcko framework: 1-(pyridin-3-yl)piperazine.
N-Alkylation: The nitrogen atoms in the piperazine ring are basic and can be alkylated by alkyl halides or other alkylating agents. This can result in the formation of various N-alkylated derivatives.
N-Acylation: Similar to N-alkylation, the nitrogen atoms can also be acylated with acyl chlorides or anhydrides, leading to the formation of N-acyl derivatives.
Ring Opening Reactions: The piperazine ring can undergo ring-opening reactions under certain conditions. For instance, it can react with electrophiles (substances that are electron-deficient) leading to the formation of open-chain compounds.
Oxidation: The compound may undergo oxidation reactions under the influence of strong oxidizing agents, potentially leading to the formation of various oxidation products.
Reduction: Conversely, it may undergo reduction reactions with suitable reducing agents.
Substitution Reactions: The pyridine ring can undergo various substitution reactions, such as electrophilic aromatic substitution or nucleophilic aromatic substitution, depending on the conditions and reagents.
Metal Complexation: The compound may also form complexes with various metal ions, depending on the nature of the metal and the reaction conditions.
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5-(4-Ethylpiperazin-1-yl)pyridin-2-amine
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tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate
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tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
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5-(4-Methylpiperazin-1-yl)picolinic acid
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1-(Pyridin-3-yl)piperazine hydrochloride
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tert-Butyl 4-(6-bromopyridin-3-yl)piperazine-1-carboxylate
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5-Bromo-3-(piperazin-1-yl)pyridin-2-amine