Chemistry Heterocyclic Building Blocks Piperazines 1-(pyridin-3-ylmethyl)piperazine

1-(pyridin-3-ylmethyl)piperazine

Ambeed provide 6 derivatives of 1-(pyridin-3-ylmethyl)piperazine.

These compounds have the same murcko framework: 1-(pyridin-3-ylmethyl)piperazine.

Alkylation or Acylation: 1-(pyridin-3-ylmethyl)piperazine can be alkylated or acylated at the nitrogen atoms on the piperazine ring. This can be achieved using appropriate alkylating agents or acylating agents. For example, you can react it with alkyl halides or acyl chlorides to introduce alkyl or acyl groups.
N-oxidation: The nitrogen atoms in the piperazine ring can be oxidized to form N-oxides under certain conditions.
Ring Opening Reactions: Piperazine rings can be opened under acidic or basic conditions to form compounds with linear chains.
Condensation Reactions: It can be used in various condensation reactions, like the formation of imines, Schiff bases, or amides.
Substitution Reactions: The pyridine moiety can undergo electrophilic aromatic substitution reactions. This can include reactions with strong electrophiles like acyl chlorides to form amides.
Heterocyclic Chemistry: The pyridine ring in the molecule can participate in various heterocyclic chemistry reactions, such as Friedel-Crafts acylation or alkylation.
Metal-Catalyzed Reactions: Transition metal catalysts can be used to facilitate various reactions involving this compound, such as cross-coupling reactions.

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Framework+−

(9H-fluoren-9-yl)methyl piperazine-1-carboxylate (R)-2-benzylpiperazine 1,4-diphenylpiperazine 1-(2-chlorophenyl)piperazine 1-(2-fluorophenyl)piperazine 1-(3-methoxyphenyl)piperazine 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine 1-(methylsulfonyl)piperazine 1-(phenylsulfonyl)piperazine 1-(piperidin-4-yl)piperazine 1-(pyridin-3-yl)piperazine 1-(pyridin-3-ylmethyl)piperazine 1-benzhydryl-4-benzylpiperazine 1-benzhydrylpiperazine 1-benzyl 4-(tert-butyl) piperazine-1,4-dicarboxylate 1-benzyl-4-methylpiperazine 1-ethyl-4-phenylpiperazine 1-ethylpiperazine 1-isopropylpiperazine 1-methyl-4-(pyridin-2-yl)piperazine 1-methyl-4-phenylpiperazine 1-methylpiperazin-2-one 1-methylpiperazine 10-(3-(piperazin-1-yl)propyl)-10H-phenothiazine 2-(4-(benzyloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(piperazin-1-yl)benzonitrile 2-(piperazin-1-yl)ethan-1-amine 2-(piperazin-1-yl)ethan-1-ol 2-(piperazin-1-yl)pyrazine 2-(piperazin-1-yl)pyrimidine 2-phenylpiperazine 3-(piperazin-1-yl)aniline 3-(piperazin-1-yl)benzoic acid 3-(piperazin-1-yl)pyridazine 3-methylpiperazin-2-one 4-(piperazin-1-yl)benzaldehyde 4-(piperazin-1-yl)pyrimidine benzyl 2-methylpiperazine-1-carboxylate benzyl 3-(hydroxymethyl)piperazine-1-carboxylate benzyl 3-methylpiperazine-1-carboxylate phenyl(piperazin-1-yl)methanone piperazine-2,5-dione tert-butyl 3-oxopiperazine-1-carboxylate tert-butyl 4-(pyridin-2-yl)piperazine-1-carboxylate tert-butyl 4-benzylpiperazine-1-carboxylate tert-butyl 4-phenylpiperazine-1-carboxylate tert-butyl piperazine-1-carboxylate

By Key Group+−

benzothiophene-piperazine benzylpiperazine boc-piperazine butylpiperazine cyanopiperazine dimethylpiperazine dioxaborolane-piperazine ethylpiperazine formylpiperazine hydroxyethyl-piperazine hydroxymethyl-piperazine-carboxylate indazo-piperazine isobutylpiperazine isopropylpiperazine methylpiperazine oxopiperazine phenylpiperazine piperazin-amine piperazin-pyrimidin piperazine-carboxylate piperazine-carboxylic acid piperazine-hydrochloride piperazine-hydroxyl piperazine-methanol piperazine-pyrazine piperazine-pyridine piperazine-quinoline propylpiperazine pyrazol-piperazine sulfonyl-piperazine trifluoromethyl-phenyl-piperazin trifluoromethyl-piperazine trimethylpiperazine

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Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzofurans Benzothiazoles Benzothiophenes Dioxolanes Furans Imidazoles Imidazolines Indazoles Indoles Morpholines Non-Halogenated Heterocycles Other Aromatic Heterocycles Oxetanes Phthalazines Piperidines Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Quinazolines Quinolines Spiroes Tetrahydrofurans Thiazoles Triazoles

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Alcohols Aldehydes Alkenyls Alkyls Alkynyls Amides Amines Aryls Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Ketones Nitriles Nitroes Organoboron Phenols Sulfamides Sulfones Sulfonic Acids Sulfonyl Chlorides Thioureas Trifluoromethyls Ureas

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