Chemistry Heterocyclic Building Blocks Pyridines 1-(pyridin-4-yl)ethan-1-one
Ambeed provide 14 derivatives of 1-(pyridin-4-yl)ethan-1-one.
These compounds have the same murcko framework: 1-(pyridin-4-yl)ethan-1-oneNucleophilic Addition: The carbonyl carbon in the ethanone portion can undergo nucleophilic addition reactions. This could involve attack by a variety of nucleophiles, such as amines, hydride ions, or organometallic reagents. The pyridine ring might also participate in the reaction depending on the conditions.
Acylation Reactions: The compound can participate in acylation reactions where the carbonyl group is attacked by nucleophiles to form a new carbon-carbon bond. For instance, reaction with Grignard reagents can lead to the formation of ketones after hydrolysis.
Condensation Reactions: The compound can undergo condensation reactions, such as the aldol condensation, where two molecules of the compound can react to form a β-hydroxy ketone, which can then dehydrate to form an α,β-unsaturated ketone.
Reduction Reactions: The carbonyl group can be reduced to the corresponding alcohol using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation Reactions: The compound can undergo oxidation reactions to convert the carbonyl group into a carboxylic acid or another oxidized functional group.
Substitution Reactions: The pyridine ring can undergo substitution reactions under appropriate conditions. For instance, nucleophilic aromatic substitution or electrophilic aromatic substitution could occur depending on the reagents and conditions.
Catalytic Hydrogenation: The compound can be hydrogenated using a catalyst such as palladium on carbon to convert the carbonyl group into a hydroxyl group.
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1-(2-(Trifluoromethyl)pyridin-4-yl)ethanone