Chemistry Heterocyclic Building Blocks Pyridines 1-benzyl-1,2,3,6-tetrahydropyridine
Ambeed provide 9 derivatives of 1-benzyl-1,2,3,6-tetrahydropyridine.
These compounds have the same murcko framework: 1-benzyl-1,2,3,6-tetrahydropyridine.
Nucleophilic Substitution: The benzyl group on the nitrogen atom can undergo nucleophilic substitution reactions with various nucleophiles. For example, you can replace the benzyl group with a different group using a strong nucleophile like sodium hydroxide (NaOH).
Oxidation: The pyridine ring in 1-benzyl-1,2,3,6-tetrahydropyridine can be oxidized to the corresponding pyridine or pyridinium derivative using oxidizing agents like potassium permanganate (KMnO4) or chromic acid (H2CrO4).
Reduction: Depending on the reaction conditions, you can reduce the pyridine ring or other functional groups in the molecule using reducing agents such as sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Alkylation: You can alkylate the pyridine ring with alkyl halides or other alkylating agents to introduce different alkyl groups onto the nitrogen atom.
Acylation: 1-Benzyl-1,2,3,6-tetrahydropyridine can undergo acylation reactions by reacting with acylating agents to replace the benzyl group with an acyl group.
Hydrogenation: The double bond in the pyridine ring can be reduced through hydrogenation reactions to form a saturated ring.
Friedel-Crafts Reactions: Friedel-Crafts reactions can be used to introduce various substituents onto the benzene ring of the benzyl group.
Rearrangements: Depending on the reaction conditions and the presence of specific reagents or catalysts, rearrangements of the molecule can occur, leading to the formation of different products.
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1-Benzyl-4-methyl-1,2,3,6-tetrahydropyridine
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(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)methanamine
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1-Benzyl-4-methyl-1,2,3,6-tetrahydropyridine hydrochloride
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Ethyl 1-benzyl-5,5-difluoro-1,2,5,6-tetrahydropyridine-3-carboxylate
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Ethyl 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate
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1-Benzyl-4-bromo-1,2,3,6-tetrahydropyridine
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1-Benzyl-5-methyl-1,2,3,6-tetrahydropyridin-4-ol
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Methyl 1-benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate