Chemistry
Heterocyclic Building Blocks
Triazoles
1-benzyl-1H-1,2,3-triazole
Acylation: You can acylate the triazole ring or the benzyl group using acylating agents like acyl chlorides or anhydrides to introduce acyl groups.
Alkylation: Alkylation reactions can be carried out to add alkyl groups to the triazole ring or the benzyl group.
Reduction: You can reduce the triazole ring or the benzyl group using reducing agents like hydrogen and a metal catalyst or chemical reducing agents to convert any nitro or carbonyl groups to amines or alcohols, respectively.
Oxidation: Oxidation reactions can be used to convert any primary or secondary alcohols in the molecule to carbonyl compounds (aldehydes or ketones).
Halogenation: You can introduce halogen atoms (such as chlorine or bromine) onto the benzyl group or other positions on the molecule using halogenating reagents.
Aromatic Substitution: If there are electron-rich positions in the molecule, they can undergo electrophilic aromatic substitution reactions.
Click Chemistry: Triazoles are commonly used in "click chemistry" reactions, particularly in copper-catalyzed azide-alkyne cycloaddition reactions. This allows for the synthesis of various compounds and functionalization of the triazole ring.
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Ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate
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5-Methyl-1-(4-methylbenzyl)-1H-1,2,3-triazol-4-amine
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5-Methyl-1-(4-(trifluoromethoxy)benzyl)-1H-1,2,3-triazol-4-amine
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1-(4-Methoxybenzyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid