Chemistry Heterocyclic Building Blocks Pyrazoles 1-benzyl-1H-pyrazolo[3,4-b]pyridine

1-benzyl-1H-pyrazolo[3,4-b]pyridine

Ambeed provide 9 derivatives of 1-benzyl-1H-pyrazolo[3,4-b]pyridine.

These compounds have the same murcko framework: 1-benzyl-1H-pyrazolo[3,4-b]pyridine.

Acylation or Alkylation: 1-Benzyl-1H-pyrazolo[3,4-b]pyridine can undergo acylation or alkylation reactions, where acyl or alkyl groups are introduced onto the nitrogen atom or the benzyl group. These reactions are often carried out using acyl chlorides or alkyl halides in the presence of a suitable base.
Reductive Reactions: The benzyl group in the molecule can undergo reduction reactions to form the corresponding benzyl alcohol or even further reduction to form the corresponding alkane. This can be achieved using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Halogenation: 1-Benzyl-1H-pyrazolo[3,4-b]pyridine can undergo halogenation reactions, where halogen atoms (e.g., chlorine, bromine) are introduced onto the aromatic ring or other suitable positions. This can be done using appropriate halogenating agents.
Oxidation: Oxidation reactions can convert the benzyl group into a benzaldehyde or further into a benzoic acid derivative. Common oxidizing agents like potassium permanganate (KMnO4) or chromic acid (CrO3) can be used for such transformations.
Ring-Opening Reactions: Depending on the reaction conditions, ring-opening reactions may occur, leading to the formation of open-chain compounds. This could happen under certain high-temperature or acidic conditions.
Substitution Reactions: The nitrogen atom in the pyrazolo[3,4-b]pyridine ring is a potential site for nucleophilic substitution reactions. This can lead to the replacement of the benzyl group with other nucleophiles.
Cyclization Reactions: Depending on the reactants and conditions, 1-Benzyl-1H-pyrazolo[3,4-b]pyridine can participate in various cyclization reactions, forming different heterocyclic compounds.

Further Reading:
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(1-methyl-1H-pyrazol-3-yl)methanol (1-phenyl-1H-pyrazol-4-yl)boronic acid 1,3-dimethyl-1H-pyrazole 1,3-diphenyl-1H-pyrazole 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1,5-diphenyl-1H-pyrazole 1-(2-chlorophenyl)-1H-pyrazole 1-(3-chlorophenyl)-1H-pyrazole 1-(4-methoxybenzyl)-1H-pyrazole 1-(azetidin-3-yl)-1H-pyrazole 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole 1-benzyl-1H-pyrazolo[3,4-b]pyridine 1-benzyl-4-bromo-1H-pyrazole 1-benzyl-4-iodo-1H-pyrazole 1-cyclopentyl-1H-pyrazole 1-cyclopropyl-1H-pyrazole 1-methyl-1H-pyrazol-3-amine 1-methyl-3-phenyl-1H-pyrazole 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-methyl-5-phenyl-1H-pyrazole 1-phenyl-1H-pyrazol-3-amine 1-phenyl-1H-pyrazol-3-ol 1-phenyl-1H-pyrazol-5-amine 1-phenyl-1H-pyrazole-3-carboxylic acid 1-phenyl-1H-pyrazole-4-carbaldehyde 1-phenyl-1H-pyrazole-4-carbonitrile 1-phenyl-1H-pyrazole-4-carboxylic acid 1-phenyl-1H-pyrazole-5-carboxylic acid 1-phenyl-3-(trifluoromethyl)-1H-pyrazole 1-trityl-1H-pyrazole 1H-pyrazol-4-amine 1H-pyrazol-4-ol 1H-pyrazol-5-amine 1H-pyrazole-4-carbaldehyde 1H-pyrazole-4-carbonitrile 1H-pyrazole-4-carboxylic acid 1H-pyrazole-4-sulfonyl chloride 1H-pyrazole-5-carboxamide 1H-pyrazole-5-carboxylic acid 1H-pyrazolo[3,4-b]pyrazine 1H-pyrazolo[3,4-b]pyridin-5-amine 1H-pyrazolo[3,4-d]pyrimidin-4-amine 1H-pyrazolo[4,3-d]pyrimidine 2,3-dihydropyrazolo[5,1-b]oxazole 2,4-dihydro-3H-pyrazol-3-one 2,6-di(1H-pyrazol-1-yl)pyridine 2-(1H-pyrazol-1-yl)pyridine 2-(1H-pyrazol-1-yl)pyrimidine 2-(1H-pyrazol-3-yl)pyridine 2-phenyl-2,4-dihydro-3H-pyrazol-3-one 3-(tert-butyl)-1-phenyl-1H-pyrazole 3-bromo-1-methyl-1H-pyrazole 3-bromopyrazolo[1,5-a]pyridine 3-bromopyrazolo[1,5-a]pyrimidine 3-chloro-1-methyl-1H-pyrazole 3-cyclopropyl-1H-pyrazole 3-iodo-1-methyl-1H-pyrazole 3-iodo-1H-pyrazolo[3,4-b]pyridine 3-methyl-1-phenyl-1H-pyrazole 3-phenyl-1H-pyrazol-5-amine 4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine 4-(1H-pyrazol-1-yl)benzoic acid 4-(1H-pyrazol-1-yl)piperidine 4-bromo-1-methyl-1H-pyrazole 4-bromo-1-phenyl-1H-pyrazole 4-bromo-1H-pyrazolo[3,4-b]pyridine 4-bromopyrazolo[1,5-a]pyridine 4-chloro-1H-pyrazole 4-chloro-1H-pyrazolo[3,4-b]pyridine 4-chloro-1H-pyrazolo[3,4-d]pyrimidine 4-iodo-1H-pyrazole 4-methyl-1-phenyl-1H-pyrazole 4-methyl-1H-pyrazole 4-nitro-1H-pyrazole 4-phenyl-1H-pyrazole 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole 5-(difluoromethyl)-1H-pyrazole 5-bromo-1H-pyrazole 5-bromo-1H-pyrazolo[3,4-b]pyridine 5-bromo-1H-pyrazolo[3,4-c]pyridine 5-chloro-1H-pyrazole 5-chloro-1H-pyrazolo[3,4-b]pyridine 5-chloropyrazolo[1,5-a]pyrimidine 5-cyclopropyl-1H-pyrazole 5-iodo-1H-pyrazole 5-nitro-1H-pyrazole 5-nitro-1H-pyrazolo[3,4-b]pyridine 5-phenyl-1H-pyrazole-3-carboxylic acid 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine 6-bromopyrazolo[1,5-a]pyridine 6-bromopyrazolo[1,5-a]pyrimidine 6-chloro-1H-pyrazolo[3,4-d]pyrimidine 7-chloropyrazolo[1,5-a]pyrimidine ethyl 1-phenyl-1H-pyrazole-3-carboxylate ethyl 1-phenyl-1H-pyrazole-4-carboxylate ethyl 1H-pyrazole-4-carboxylate ethyl pyrazolo[1,5-a]pyridine-3-carboxylate ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate methyl 1H-pyrazole-4-carboxylate methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate methyl pyrazolo[1,5-a]pyridine-3-carboxylate pyrazolo[1,5-a]pyrazine pyrazolo[1,5-a]pyridine-2-carboxylic acid pyrazolo[1,5-a]pyridine-3-carboxylic acid pyrazolo[1,5-a]pyrimidine-3-carboxylic acid tert-butyl 1H-pyrazolo[3,4-b]pyridine-1-carboxylate tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

By Key Group+−

1-Cyclopropyl-1H-pyrazole amino-pyrazole-carboxylate amino-pyrazolopyridine amino-pyrazolopyrimidine aminopyrazolo benzylpyrazol-amide bipyrazole bromo-methyl-pyrazole bromo-pyrazol-amide bromo-pyrazole-carboxylate bromo-pyrazolopyridine bromo-pyrazolopyrimidine bromo-trifluoromethyl-pyrazole bromopyrazolo chloro-methyl-pyrazole chloro-pyrazolamide chloro-pyrazole chloro-pyrazole-carboxylate chloro-pyrazolopyridine chloro-pyrazolopyrimidine chloropyrazolo dichloropyrazolo difluoromethyl-pyrazole difluoromethyl-pyrazole-carboxylate dihydropyrazolo dimethyl-pyrazol-amide dimethyl-pyrazole-carboxylate dimethyl-pyrazole-carboxylic acid dimethylpyrazole dimethylpyrazolo dioxaborolan-pyrazole ethyl-pyrazol-amide ethylpyrazole fluoropyrazolo hydroxy-pyrazole hydroxy-pyrazolopyrimidine hydroxypyrazolo iodo-methyl-pyrazole iodo-pyrazole-carboxylate iodopyrazolo isopropyl-pyrazol-amide methoxy-pyrazolo-pyridine methoxypyrazolo methy-pyrazolooxazine methyl-hydrox-ypyrazole methyl-nitro-pyrazole methyl-pyrazol-one methyl-pyrazole-carboxylic acid methyl-pyrazolopyridine methylpyrazole methylpyrazolo nitro-pyrazole-carboxylate phenyl-pyrazol-amide phenyl-pyrazole-carboxylate phenyl-pyrazolidine phenylpyrazole pyrazo-morpholine pyrazol-amine pyrazol-boronic acid pyrazol-methanol pyrazol-one pyrazol-piperazine pyrazol-pyridine pyrazole-carbonitrile pyrazole-carboxylate pyrazole-carboxylic acid pyrazole-ethanol pyrazole-hydrochloride pyrazole-methamine pyrazole-phenyl-boronic acid/ester pyrazole-piperidine pyrazolo-pyrimidine pyrazolooxazine pyrazolopyrazine pyrazolopyridin-ol pyrazolopyridin-one pyrazolopyridine pyrazolopyridine-carbonitrile pyrazolopyridine-carboxylate pyrazolopyridine-carboxylic acid pyrazolopyridine-methanol pyrazolopyrimid-one pyrazolopyrimidine pyrazolotriazine pyridine-pyrazole pyrrolopyrazole tetrahydropyran-pyrazole tetrahydropyranopyrazole tetrahydropyrazolo trifluoromethyl-phenyl-pyrazol trifluoromethyl-pyrazol-amide trifluoromethyl-pyrazole trifluoromethyl-pyrazolone

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Azetidines Furans Guanidines Imidazoles Indazoles Indoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxetanes Piperazines Piperidines Pyrazines Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Quinolines Tetrahydrofurans Tetrahydropyrans Thiophenes

By Functional Group+−

Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Benzyl bromides Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazones Iodides Ketones Nitriles Nitroes Organoboron Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfonic Acids Sulfonyl Chlorides Trifluoromethyls Ureas

By Chemical Elements+−

    Bx
    Cx
    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

    Druglikeness+−

    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    By Configuration+−

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