Chemistry Organic Building Blocks Bromides 1-bromo-2,3-difluorobenzene
Ambeed provide 38 derivatives of 1-bromo-2,3-difluorobenzene.
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Br,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal alkynes using a palladium catalyst, leading to the formation of substituted alkynes.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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1-Bromo-2,3-difluoro-4-methoxybenzene
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1-Bromo-4-ethoxy-2,3-difluorobenzene
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(4-Bromo-2,3,5,6-tetrafluorophenyl)boronic acid
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2-(4-Bromo-2,3,6-trifluorophenyl)acetic acid
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1-Bromo-2,3-difluoro-4-(trifluoromethyl)benzene
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tert-Butyl 2-bromo-3,4-difluorobenzylcarbamate
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4-Bromo-2,3,5,6-tetrafluorobenzaldehyde
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Methyl 4-bromo-2,3,5,6-tetrafluorobenzoate