Chemistry Organic Building Blocks Bromides 1-bromo-2-(methylsulfonyl)benzene
Ambeed provide 4 derivatives of 1-bromo-2-(methylsulfonyl)benzene.
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Br,—SO2CH3).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Sulfonation: Under certain conditions, (methylsulfonyl)benzene can be sulfonated to introduce a sulfonic acid group (-SO3H) onto the benzene ring. This can be achieved using concentrated sulfuric acid (H2SO4) and heat. The sulfonyl group is replaced by a sulfonic acid group in this reaction.
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Methyl 3-bromo-4-(methylsulfonyl)benzoate
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2-Bromo-4-fluoro-1-(methylsulfonyl)benzene