Chemistry Organic Building Blocks Bromides 1-bromo-2-(trifluoromethoxy)benzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —Br,—OCF3).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Nucleophilic Aromatic Substitution (NAS): In some cases, under appropriate conditions, nucleophiles can attack the benzene ring, leading to nucleophilic aromatic substitution reactions. The trifluoromethoxy group can influence the reactivity of the ring.
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1-Bromo-4-fluoro-2-(trifluoromethoxy)benzene
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Methyl 3-bromo-4-(trifluoromethoxy)benzoate
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2-Bromo-4-nitro-1-(trifluoromethoxy)benzene
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2-Bromo-4-methyl-1-(trifluoromethoxy)benzene
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2-Bromo-4-fluoro-1-(trifluoromethoxy)benzene
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2-Bromo-4-chloro-1-(trifluoromethoxy)benzene
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1-Bromo-4-methoxy-2-(trifluoromethoxy)benzene